Tags

Type your tag names separated by a space and hit enter

Interaction between impulse-flow and delta 9-tetrahydrocannabinol within the septal-hippocampal cholinergic pathway of rat brain.
J Pharmacol Exp Ther. 1981 Nov; 219(2):580-4.JP

Abstract

The role of the cholinergic cell bodies of the medial septum in the transsynaptic reduction of nerve activity elicited by delta 9-tetrahydrocannabinol (THC) in the septal-hippocampal cholinergic pathway was assessed by measuring the ability of delta 9-THC to reduce sodium-dependent high affinity choline uptake in rat hippocampus 2 hr after electrolytic destruction of the cholinergic cell bodies in the septum. delta 9-THC did not reduce choline uptake in rats with electrolytic lesions of the cholinergic cell bodies in the septum. Because lesioning of cholinergic cell bodies itself reduces impulse-flow in cholinergic neurons, this observation has two interpretations: either delta 9-THC acts transynaptically at the cholinergic cell bodies in the septum, or alternatively, requires impulse-flow in the septal-hippocampal cholinergic pathway in order to reduce its activity. To test if delta 9-THC required impulse-flow in order to reduce the activity or the septal-hippocampal cholinergic pathway, the ability of delta 9-THC to reduce choline uptake in hippocampus of rats with cingulate bundle transections, another surgical procedure which reduces impulse-flow iun the septal-hippocampal cholinergic pathway, was measured. In cingulate bundle-transected rats, delta 9-THC did not reduce choline uptake in hippocampus. Taken together with the effects of delta 9-THC in septal-lesioned rats, this observation favors the interpretation that delta 9-THC requires impulse-flow in the septal-hippocampal cholinergic pathway in order to reduce the activity of this pathway.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6270316

Citation

Lindamood, C, and B K. Colasanti. "Interaction Between Impulse-flow and Delta 9-tetrahydrocannabinol Within the Septal-hippocampal Cholinergic Pathway of Rat Brain." The Journal of Pharmacology and Experimental Therapeutics, vol. 219, no. 2, 1981, pp. 580-4.
Lindamood C, Colasanti BK. Interaction between impulse-flow and delta 9-tetrahydrocannabinol within the septal-hippocampal cholinergic pathway of rat brain. J Pharmacol Exp Ther. 1981;219(2):580-4.
Lindamood, C., & Colasanti, B. K. (1981). Interaction between impulse-flow and delta 9-tetrahydrocannabinol within the septal-hippocampal cholinergic pathway of rat brain. The Journal of Pharmacology and Experimental Therapeutics, 219(2), 580-4.
Lindamood C, Colasanti BK. Interaction Between Impulse-flow and Delta 9-tetrahydrocannabinol Within the Septal-hippocampal Cholinergic Pathway of Rat Brain. J Pharmacol Exp Ther. 1981;219(2):580-4. PubMed PMID: 6270316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction between impulse-flow and delta 9-tetrahydrocannabinol within the septal-hippocampal cholinergic pathway of rat brain. AU - Lindamood,C,3rd AU - Colasanti,B K, PY - 1981/11/1/pubmed PY - 1981/11/1/medline PY - 1981/11/1/entrez SP - 580 EP - 4 JF - The Journal of pharmacology and experimental therapeutics JO - J Pharmacol Exp Ther VL - 219 IS - 2 N2 - The role of the cholinergic cell bodies of the medial septum in the transsynaptic reduction of nerve activity elicited by delta 9-tetrahydrocannabinol (THC) in the septal-hippocampal cholinergic pathway was assessed by measuring the ability of delta 9-THC to reduce sodium-dependent high affinity choline uptake in rat hippocampus 2 hr after electrolytic destruction of the cholinergic cell bodies in the septum. delta 9-THC did not reduce choline uptake in rats with electrolytic lesions of the cholinergic cell bodies in the septum. Because lesioning of cholinergic cell bodies itself reduces impulse-flow in cholinergic neurons, this observation has two interpretations: either delta 9-THC acts transynaptically at the cholinergic cell bodies in the septum, or alternatively, requires impulse-flow in the septal-hippocampal cholinergic pathway in order to reduce its activity. To test if delta 9-THC required impulse-flow in order to reduce the activity or the septal-hippocampal cholinergic pathway, the ability of delta 9-THC to reduce choline uptake in hippocampus of rats with cingulate bundle transections, another surgical procedure which reduces impulse-flow iun the septal-hippocampal cholinergic pathway, was measured. In cingulate bundle-transected rats, delta 9-THC did not reduce choline uptake in hippocampus. Taken together with the effects of delta 9-THC in septal-lesioned rats, this observation favors the interpretation that delta 9-THC requires impulse-flow in the septal-hippocampal cholinergic pathway in order to reduce the activity of this pathway. SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/6270316/Interaction_between_impulse_flow_and_delta_9_tetrahydrocannabinol_within_the_septal_hippocampal_cholinergic_pathway_of_rat_brain_ L2 - https://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=6270316 DB - PRIME DP - Unbound Medicine ER -