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Levonantradol-induced inhibition of acetylcholine turnover in rat hippocampus and striatum.
J Clin Pharmacol. 1981 Aug-Sep; 21(S1):256S-261S.JC

Abstract

The effects of levonantradol, a structural novel cannabinoid-related analgesic, on the turnover rate of acetylcholine (TRACh) have been studied in various regions of the rat brain. Levonantradol (0.3 mg/kg subcutaneously) decreases the tRACh in the hippocampus and striatum by 53 and 30 per cent, respectively. The extent of the reduction in TRACh is dose dependent, with a maximal decrease of 80 per cent in the hippocampus and 57 per cent in the striatum following the 3 mg/kg dose. In contrast, cortical TRACh is not affected by any dose of levonantradol. This pattern of activity on cholinergic dynamics elicited by levonantradol is qualitatively similar to that of cannabinoids but differs from that previously reported for narcotic analgesics. Moreover naltrexone (2 mg/kg intraperitoneally) does not reverse the effects of levonantradol on striatal or hippocampal TRACh. This pattern of activity on cholinergic dynamics elicited by levonantradol is consistent with a cannabinoid-like rather than an opioid-like mode of action.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6271831

Citation

Costa, E, et al. "Levonantradol-induced Inhibition of Acetylcholine Turnover in Rat Hippocampus and Striatum." Journal of Clinical Pharmacology, vol. 21, no. S1, 1981, 256S-261S.
Costa E, Cheney DL, Murray TF. Levonantradol-induced inhibition of acetylcholine turnover in rat hippocampus and striatum. J Clin Pharmacol. 1981;21(S1):256S-261S.
Costa, E., Cheney, D. L., & Murray, T. F. (1981). Levonantradol-induced inhibition of acetylcholine turnover in rat hippocampus and striatum. Journal of Clinical Pharmacology, 21(S1), 256S-261S.
Costa E, Cheney DL, Murray TF. Levonantradol-induced Inhibition of Acetylcholine Turnover in Rat Hippocampus and Striatum. J Clin Pharmacol. 1981 Aug-Sep;21(S1):256S-261S. PubMed PMID: 6271831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Levonantradol-induced inhibition of acetylcholine turnover in rat hippocampus and striatum. AU - Costa,E, AU - Cheney,D L, AU - Murray,T F, PY - 1981/8/1/pubmed PY - 1981/8/1/medline PY - 1981/8/1/entrez SP - 256S EP - 261S JF - Journal of clinical pharmacology JO - J Clin Pharmacol VL - 21 IS - S1 N2 - The effects of levonantradol, a structural novel cannabinoid-related analgesic, on the turnover rate of acetylcholine (TRACh) have been studied in various regions of the rat brain. Levonantradol (0.3 mg/kg subcutaneously) decreases the tRACh in the hippocampus and striatum by 53 and 30 per cent, respectively. The extent of the reduction in TRACh is dose dependent, with a maximal decrease of 80 per cent in the hippocampus and 57 per cent in the striatum following the 3 mg/kg dose. In contrast, cortical TRACh is not affected by any dose of levonantradol. This pattern of activity on cholinergic dynamics elicited by levonantradol is qualitatively similar to that of cannabinoids but differs from that previously reported for narcotic analgesics. Moreover naltrexone (2 mg/kg intraperitoneally) does not reverse the effects of levonantradol on striatal or hippocampal TRACh. This pattern of activity on cholinergic dynamics elicited by levonantradol is consistent with a cannabinoid-like rather than an opioid-like mode of action. SN - 0091-2700 UR - https://www.unboundmedicine.com/medline/citation/6271831/Levonantradol_induced_inhibition_of_acetylcholine_turnover_in_rat_hippocampus_and_striatum_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0091-2700&date=1981&volume=21&spage=256S DB - PRIME DP - Unbound Medicine ER -