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Nabilone: an effective antiemetic in patients receiving cancer chemotherapy.
J Clin Pharmacol 1981 Aug-Sep; 21(S1):64S-69SJC

Abstract

Eighty evaluable patients receiving chemotherapy were entered on a random prospective double-blind study to evaluate the effectiveness of nabilone, a synthetic cannabinoid, compared to prochlorperazine. Most of these patients received cisplatin, a drug that universally produces severe nausea and vomiting, as part of a combination chemotherapy regimen. The patients served as their own controls, receiving either nabilone or prochlorperazine during two consecutive treatment courses with the identical chemotherapy. Side effects consisting of hypotension and lethargy were more pronounced with nabilone. Toxicity, in general, did not preclude antiemetic treatment and in no way interfered with chemotherapy. Sixty patients (75 per cent) reported nabilone to be more effective than prochlorperazine for relief of nausea and vomiting. Of these 60 patients, 46 required further chemotherapy and continued taking nabilone as the antiemetic of choice.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

6271844

Citation

Einhorn, L H., et al. "Nabilone: an Effective Antiemetic in Patients Receiving Cancer Chemotherapy." Journal of Clinical Pharmacology, vol. 21, no. S1, 1981, 64S-69S.
Einhorn LH, Nagy C, Furnas B, et al. Nabilone: an effective antiemetic in patients receiving cancer chemotherapy. J Clin Pharmacol. 1981;21(S1):64S-69S.
Einhorn, L. H., Nagy, C., Furnas, B., & Williams, S. D. (1981). Nabilone: an effective antiemetic in patients receiving cancer chemotherapy. Journal of Clinical Pharmacology, 21(S1), 64S-69S.
Einhorn LH, et al. Nabilone: an Effective Antiemetic in Patients Receiving Cancer Chemotherapy. J Clin Pharmacol. 1981;21(S1):64S-69S. PubMed PMID: 6271844.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nabilone: an effective antiemetic in patients receiving cancer chemotherapy. AU - Einhorn,L H, AU - Nagy,C, AU - Furnas,B, AU - Williams,S D, PY - 1981/8/1/pubmed PY - 1981/8/1/medline PY - 1981/8/1/entrez SP - 64S EP - 69S JF - Journal of clinical pharmacology JO - J Clin Pharmacol VL - 21 IS - S1 N2 - Eighty evaluable patients receiving chemotherapy were entered on a random prospective double-blind study to evaluate the effectiveness of nabilone, a synthetic cannabinoid, compared to prochlorperazine. Most of these patients received cisplatin, a drug that universally produces severe nausea and vomiting, as part of a combination chemotherapy regimen. The patients served as their own controls, receiving either nabilone or prochlorperazine during two consecutive treatment courses with the identical chemotherapy. Side effects consisting of hypotension and lethargy were more pronounced with nabilone. Toxicity, in general, did not preclude antiemetic treatment and in no way interfered with chemotherapy. Sixty patients (75 per cent) reported nabilone to be more effective than prochlorperazine for relief of nausea and vomiting. Of these 60 patients, 46 required further chemotherapy and continued taking nabilone as the antiemetic of choice. SN - 0091-2700 UR - https://www.unboundmedicine.com/medline/citation/6271844/Nabilone:_an_effective_antiemetic_in_patients_receiving_cancer_chemotherapy_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0091-2700&date=1981&volume=21&spage=64S DB - PRIME DP - Unbound Medicine ER -