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Phosphate metabolism in renal stone formers. (II): Relation to renal tubular functions and calcium metabolism.
Scand J Urol Nephrol Suppl. 1981; 61:II:1-26.SJ

Abstract

Patients with idiopathic recurrent calcium nephrolithiasis (n = 57) and controls (n = 16) were investigated regarding the relationship between renal phosphate handling, other renal tubular functions and calcium metabolism. Incomplete renal tubular acidosis (RTA) was disclosed in 13 patients. RTA patients together with stone formers with normal renal acidification capacity (SF) exhibited low values for serum phosphate and renal threshold phosphate concentration (TmP/GFR) compared with controls. TmP/GFR was lower in RTA patients than in stone formers with normal renal acidification. Hypercalciuria of the absorptive type with normal serum PTH and urinary cAMP concentrations was a common finding in both stone patient groups, whereas no patient displayed unequivocal evidence of parathyroid hyperfunction. Fractional excretion of sodium was raised in both SF and RTA patients compared with controls. There was a positive relationship between the fractional excretion of phosphate and sodium in all subjects as a group. TmP/GFR was negatively correlated to fractional excretion of sodium. Twenty-three percent of RTA patients and 8% of SF displayed tubular proteinuria which often was associated with low TmP/GFR levels and enhanced natriuresis. It is concluded that a defective renal tubular phosphate handling is common in calcium stone formers and often associated with signs of other tubular dysfunctions. The altered phosphate handling seems to be unrelated to hypercalciuria.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6274002

Citation

Wikström, B, et al. "Phosphate Metabolism in Renal Stone Formers. (II): Relation to Renal Tubular Functions and Calcium Metabolism." Scandinavian Journal of Urology and Nephrology. Supplementum, vol. 61, 1981, pp. II:1-26.
Wikström B, Backman U, Danielson BG, et al. Phosphate metabolism in renal stone formers. (II): Relation to renal tubular functions and calcium metabolism. Scand J Urol Nephrol Suppl. 1981;61:II:1-26.
Wikström, B., Backman, U., Danielson, B. G., Fellström, B., Johansson, G., Ljunghall, S., & Wide, L. (1981). Phosphate metabolism in renal stone formers. (II): Relation to renal tubular functions and calcium metabolism. Scandinavian Journal of Urology and Nephrology. Supplementum, 61, II:1-26.
Wikström B, et al. Phosphate Metabolism in Renal Stone Formers. (II): Relation to Renal Tubular Functions and Calcium Metabolism. Scand J Urol Nephrol Suppl. 1981;61:II:1-26. PubMed PMID: 6274002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phosphate metabolism in renal stone formers. (II): Relation to renal tubular functions and calcium metabolism. AU - Wikström,B, AU - Backman,U, AU - Danielson,B G, AU - Fellström,B, AU - Johansson,G, AU - Ljunghall,S, AU - Wide,L, PY - 1981/1/1/pubmed PY - 1981/1/1/medline PY - 1981/1/1/entrez SP - II:1-26 JF - Scandinavian journal of urology and nephrology. Supplementum JO - Scand J Urol Nephrol Suppl VL - 61 N2 - Patients with idiopathic recurrent calcium nephrolithiasis (n = 57) and controls (n = 16) were investigated regarding the relationship between renal phosphate handling, other renal tubular functions and calcium metabolism. Incomplete renal tubular acidosis (RTA) was disclosed in 13 patients. RTA patients together with stone formers with normal renal acidification capacity (SF) exhibited low values for serum phosphate and renal threshold phosphate concentration (TmP/GFR) compared with controls. TmP/GFR was lower in RTA patients than in stone formers with normal renal acidification. Hypercalciuria of the absorptive type with normal serum PTH and urinary cAMP concentrations was a common finding in both stone patient groups, whereas no patient displayed unequivocal evidence of parathyroid hyperfunction. Fractional excretion of sodium was raised in both SF and RTA patients compared with controls. There was a positive relationship between the fractional excretion of phosphate and sodium in all subjects as a group. TmP/GFR was negatively correlated to fractional excretion of sodium. Twenty-three percent of RTA patients and 8% of SF displayed tubular proteinuria which often was associated with low TmP/GFR levels and enhanced natriuresis. It is concluded that a defective renal tubular phosphate handling is common in calcium stone formers and often associated with signs of other tubular dysfunctions. The altered phosphate handling seems to be unrelated to hypercalciuria. SN - 0300-8886 UR - https://www.unboundmedicine.com/medline/citation/6274002/Phosphate_metabolism_in_renal_stone_formers___II_:_Relation_to_renal_tubular_functions_and_calcium_metabolism_ DB - PRIME DP - Unbound Medicine ER -