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Enhanced angiotensin-mediated facilitation of adrenergic neurotransmission in spontaneously hypertensive rats.
J Pharmacol Exp Ther. 1982 Apr; 221(1):112-6.JP

Abstract

The effect of angiotensin II on the pressor response of the mesenteric vascular bed to periarterial adrenergic nerve stimulation (PNS) was compared between spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY). Angiotensin II (1-20 ng/ml) caused a marked potentiation of the vasoconstrictor response to PNS (8 Hz, 2 msec, for 30 sec) in a concentration-dependent manner without significantly affecting the base-line perfusion pressure in either WKY or SHR. The facilitatory effect of angiotensin II was significantly greater in SHR than in WKY preparations. The effective concentration for the peptide in SHR was approximately one-third of that found in WKY. Angiotensin II also potentiated the pressor response to exogenously administered norepinephrine (NE, 50 ng) in both WKY and SHR. The degree of potentiation of the response to PNS was greater than that to NE in SHR, while this differential was found only at high concentrations of angiotensin II on the WKY. The facilitatory effect of angiotensin II on the pressor response to either PNS or NE was markedly reduced by [Sar1-Ile8]angiotensin II (200 ng/ml) in both WKY and SHR. Angiotensin II caused further potentiation of the vasoconstrictor response to PNS or NE infusion in the presence of cocaine (5 micrograms/ml), which was of a greater magnitude in SHR than in WKY. These results suggest that the presynaptic facilitatory modulation of adrenergic vascular neurotransmission, mediated by angiotensin II receptors, is enhanced in the perfused mesenteric vascular bed of SHR.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6278133

Citation

Kawasaki, H, et al. "Enhanced Angiotensin-mediated Facilitation of Adrenergic Neurotransmission in Spontaneously Hypertensive Rats." The Journal of Pharmacology and Experimental Therapeutics, vol. 221, no. 1, 1982, pp. 112-6.
Kawasaki H, Cline WH, Su C. Enhanced angiotensin-mediated facilitation of adrenergic neurotransmission in spontaneously hypertensive rats. J Pharmacol Exp Ther. 1982;221(1):112-6.
Kawasaki, H., Cline, W. H., & Su, C. (1982). Enhanced angiotensin-mediated facilitation of adrenergic neurotransmission in spontaneously hypertensive rats. The Journal of Pharmacology and Experimental Therapeutics, 221(1), 112-6.
Kawasaki H, Cline WH, Su C. Enhanced Angiotensin-mediated Facilitation of Adrenergic Neurotransmission in Spontaneously Hypertensive Rats. J Pharmacol Exp Ther. 1982;221(1):112-6. PubMed PMID: 6278133.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhanced angiotensin-mediated facilitation of adrenergic neurotransmission in spontaneously hypertensive rats. AU - Kawasaki,H, AU - Cline,W H,Jr AU - Su,C, PY - 1982/4/1/pubmed PY - 2001/3/28/medline PY - 1982/4/1/entrez SP - 112 EP - 6 JF - The Journal of pharmacology and experimental therapeutics JO - J Pharmacol Exp Ther VL - 221 IS - 1 N2 - The effect of angiotensin II on the pressor response of the mesenteric vascular bed to periarterial adrenergic nerve stimulation (PNS) was compared between spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY). Angiotensin II (1-20 ng/ml) caused a marked potentiation of the vasoconstrictor response to PNS (8 Hz, 2 msec, for 30 sec) in a concentration-dependent manner without significantly affecting the base-line perfusion pressure in either WKY or SHR. The facilitatory effect of angiotensin II was significantly greater in SHR than in WKY preparations. The effective concentration for the peptide in SHR was approximately one-third of that found in WKY. Angiotensin II also potentiated the pressor response to exogenously administered norepinephrine (NE, 50 ng) in both WKY and SHR. The degree of potentiation of the response to PNS was greater than that to NE in SHR, while this differential was found only at high concentrations of angiotensin II on the WKY. The facilitatory effect of angiotensin II on the pressor response to either PNS or NE was markedly reduced by [Sar1-Ile8]angiotensin II (200 ng/ml) in both WKY and SHR. Angiotensin II caused further potentiation of the vasoconstrictor response to PNS or NE infusion in the presence of cocaine (5 micrograms/ml), which was of a greater magnitude in SHR than in WKY. These results suggest that the presynaptic facilitatory modulation of adrenergic vascular neurotransmission, mediated by angiotensin II receptors, is enhanced in the perfused mesenteric vascular bed of SHR. SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/6278133/Enhanced_angiotensin_mediated_facilitation_of_adrenergic_neurotransmission_in_spontaneously_hypertensive_rats_ L2 - https://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=6278133 DB - PRIME DP - Unbound Medicine ER -