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Iodine-induced hypothyroidism and goiter following lipiodolTM lymphography.
Eur J Pediatr. 1982 Feb; 138(1):82-3.EJ

Abstract

Hypothyroid goiter is a rare but well recognized complication following long term administration of iodine containing expectorants and disinfectants in children. Only few reports exist on iodine-induced hypothyroidism after a single injection of the iodized radiopaque dye Lipiodol. A 15-year-old boy with previously normal thyroid function is described who developed hypothyroid goiter within six weeks following bipedal lymphography. Urinary iodine excretion was extremely elevated up to 18 mg/day while serum concentrations of total thyroxine were below the euthyroid range and thyrotropin levels were elevated. After oral L-thyroxine treatment the goiter disappeared. Thyroid function remained normal when treatment was discontinued after five months although iodine excretion was still 50 times higher (2.5 mg/day) than in normal age matched children. The observed alterations of the thyroid gland were caused by a long lasting Wolff-Chaikoff effect with a delayed adaptation to high iodide concentrations.

Authors

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Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

6281022

Citation

Heidemann, P H., et al. "Iodine-induced Hypothyroidism and Goiter Following lipiodolTM Lymphography." European Journal of Pediatrics, vol. 138, no. 1, 1982, pp. 82-3.
Heidemann PH, Stubbe P, Schürnbrand P, et al. Iodine-induced hypothyroidism and goiter following lipiodolTM lymphography. Eur J Pediatr. 1982;138(1):82-3.
Heidemann, P. H., Stubbe, P., Schürnbrand, P., & Prindull, G. (1982). Iodine-induced hypothyroidism and goiter following lipiodolTM lymphography. European Journal of Pediatrics, 138(1), 82-3.
Heidemann PH, et al. Iodine-induced Hypothyroidism and Goiter Following lipiodolTM Lymphography. Eur J Pediatr. 1982;138(1):82-3. PubMed PMID: 6281022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iodine-induced hypothyroidism and goiter following lipiodolTM lymphography. AU - Heidemann,P H, AU - Stubbe,P, AU - Schürnbrand,P, AU - Prindull,G, PY - 1982/2/1/pubmed PY - 1982/2/1/medline PY - 1982/2/1/entrez SP - 82 EP - 3 JF - European journal of pediatrics JO - Eur. J. Pediatr. VL - 138 IS - 1 N2 - Hypothyroid goiter is a rare but well recognized complication following long term administration of iodine containing expectorants and disinfectants in children. Only few reports exist on iodine-induced hypothyroidism after a single injection of the iodized radiopaque dye Lipiodol. A 15-year-old boy with previously normal thyroid function is described who developed hypothyroid goiter within six weeks following bipedal lymphography. Urinary iodine excretion was extremely elevated up to 18 mg/day while serum concentrations of total thyroxine were below the euthyroid range and thyrotropin levels were elevated. After oral L-thyroxine treatment the goiter disappeared. Thyroid function remained normal when treatment was discontinued after five months although iodine excretion was still 50 times higher (2.5 mg/day) than in normal age matched children. The observed alterations of the thyroid gland were caused by a long lasting Wolff-Chaikoff effect with a delayed adaptation to high iodide concentrations. SN - 0340-6199 UR - https://www.unboundmedicine.com/medline/citation/6281022/Iodine_induced_hypothyroidism_and_goiter_following_lipiodolTM_lymphography_ L2 - https://medlineplus.gov/hypothyroidism.html DB - PRIME DP - Unbound Medicine ER -