Tags

Type your tag names separated by a space and hit enter

Electrophysiologic and histologic studies in leprosy and some acrodystrophic neuropathies.
Int J Lepr Other Mycobact Dis. 1981 Dec; 49(4):398-405.IJ

Abstract

In vitro electrophysiologic and light microscopic studies were carried out on the sural nerve in six patients with non-leprous neuropathy with plantar ulceration and in six patients with various types of leprous neuropathy. In the non-leprous group (with congenital and acquired neuropathy) the abnormalities in the compound action potentials of the myelinated (large and small) fibers were usually more striking than those in the unmyelinated fibers potentials. In the leprous neuropathies, on the other hand, the three major fiber groups tended to be involved indiscriminately, the unmyelinated fiber potential being as liable to abnormality as the myelinated fiber potentials. Histologically the nerve fiber damage in the congenital neuropathies appeared to be moderate to gross involvement of the myelinated fibers without the prominent demyelination and degeneration/regeneration seen in leprosy and the other acquired neuropathies. Leprous neuropathy showed, besides fiber abnormalities, the simultaneous deleterious effects of inflammation and fibrosis. It is a matter for speculation whether disturbed conduction in the large myelinated touch-pressure mediating fibers contributes significantly to impaired pain perception (mediated by small fibers) and plantar ulceration in leprosy and other acrodystrophic neuropathies.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6281202

Citation

Pandya, S S., and R G. Chulawala. "Electrophysiologic and Histologic Studies in Leprosy and some Acrodystrophic Neuropathies." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 49, no. 4, 1981, pp. 398-405.
Pandya SS, Chulawala RG. Electrophysiologic and histologic studies in leprosy and some acrodystrophic neuropathies. Int J Lepr Other Mycobact Dis. 1981;49(4):398-405.
Pandya, S. S., & Chulawala, R. G. (1981). Electrophysiologic and histologic studies in leprosy and some acrodystrophic neuropathies. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 49(4), 398-405.
Pandya SS, Chulawala RG. Electrophysiologic and Histologic Studies in Leprosy and some Acrodystrophic Neuropathies. Int J Lepr Other Mycobact Dis. 1981;49(4):398-405. PubMed PMID: 6281202.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrophysiologic and histologic studies in leprosy and some acrodystrophic neuropathies. AU - Pandya,S S, AU - Chulawala,R G, PY - 1981/12/1/pubmed PY - 1981/12/1/medline PY - 1981/12/1/entrez SP - 398 EP - 405 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 49 IS - 4 N2 - In vitro electrophysiologic and light microscopic studies were carried out on the sural nerve in six patients with non-leprous neuropathy with plantar ulceration and in six patients with various types of leprous neuropathy. In the non-leprous group (with congenital and acquired neuropathy) the abnormalities in the compound action potentials of the myelinated (large and small) fibers were usually more striking than those in the unmyelinated fibers potentials. In the leprous neuropathies, on the other hand, the three major fiber groups tended to be involved indiscriminately, the unmyelinated fiber potential being as liable to abnormality as the myelinated fiber potentials. Histologically the nerve fiber damage in the congenital neuropathies appeared to be moderate to gross involvement of the myelinated fibers without the prominent demyelination and degeneration/regeneration seen in leprosy and the other acquired neuropathies. Leprous neuropathy showed, besides fiber abnormalities, the simultaneous deleterious effects of inflammation and fibrosis. It is a matter for speculation whether disturbed conduction in the large myelinated touch-pressure mediating fibers contributes significantly to impaired pain perception (mediated by small fibers) and plantar ulceration in leprosy and other acrodystrophic neuropathies. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/6281202/Electrophysiologic_and_histologic_studies_in_leprosy_and_some_acrodystrophic_neuropathies_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -