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A longitudinal study of respiratory viruses and bacteria in the etiology of acute otitis media with effusion.
N Engl J Med. 1982 Jun 10; 306(23):1377-83.NEJM

Abstract

We analyzed data from a 14-year longitudinal study of respiratory infections in young children to determine the relative importance of viral respiratory infection and nasopharyngeal colonization with Streptococcus pneumoniae and Haemophilus influenzae as factors influencing the occurrence of acute otitis media with effusion. The incidence of this disorder was increased in children with viral respiratory infections (average relative risk, 3.2; P less than 0.0001). Infection with respiratory syncytial virus, influenza virus (type A or B), and adenovirus conferred a greater risk of otitis media than did infection with parainfluenza virus, enterovirus, or rhinovirus. Colonization of the nasopharynx with Str. pneumoniae or H. influenzae had a lesser effect on the incidence of the disease (average relative risk; 1.5; P less than 0.01). Infections with the viruses more closely associated with acute otitis media (respiratory syncytial virus, adenovirus, and influenza A or B) were correlated with an increased risk of recurrent disease. Prevention of selected otitis-associated viral infections should reduce the incidence of this disease.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6281639

Citation

Henderson, F W., et al. "A Longitudinal Study of Respiratory Viruses and Bacteria in the Etiology of Acute Otitis Media With Effusion." The New England Journal of Medicine, vol. 306, no. 23, 1982, pp. 1377-83.
Henderson FW, Collier AM, Sanyal MA, et al. A longitudinal study of respiratory viruses and bacteria in the etiology of acute otitis media with effusion. N Engl J Med. 1982;306(23):1377-83.
Henderson, F. W., Collier, A. M., Sanyal, M. A., Watkins, J. M., Fairclough, D. L., Clyde, W. A., & Denny, F. W. (1982). A longitudinal study of respiratory viruses and bacteria in the etiology of acute otitis media with effusion. The New England Journal of Medicine, 306(23), 1377-83.
Henderson FW, et al. A Longitudinal Study of Respiratory Viruses and Bacteria in the Etiology of Acute Otitis Media With Effusion. N Engl J Med. 1982 Jun 10;306(23):1377-83. PubMed PMID: 6281639.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A longitudinal study of respiratory viruses and bacteria in the etiology of acute otitis media with effusion. AU - Henderson,F W, AU - Collier,A M, AU - Sanyal,M A, AU - Watkins,J M, AU - Fairclough,D L, AU - Clyde,W A,Jr AU - Denny,F W, PY - 1982/6/10/pubmed PY - 2001/3/28/medline PY - 1982/6/10/entrez SP - 1377 EP - 83 JF - The New England journal of medicine JO - N Engl J Med VL - 306 IS - 23 N2 - We analyzed data from a 14-year longitudinal study of respiratory infections in young children to determine the relative importance of viral respiratory infection and nasopharyngeal colonization with Streptococcus pneumoniae and Haemophilus influenzae as factors influencing the occurrence of acute otitis media with effusion. The incidence of this disorder was increased in children with viral respiratory infections (average relative risk, 3.2; P less than 0.0001). Infection with respiratory syncytial virus, influenza virus (type A or B), and adenovirus conferred a greater risk of otitis media than did infection with parainfluenza virus, enterovirus, or rhinovirus. Colonization of the nasopharynx with Str. pneumoniae or H. influenzae had a lesser effect on the incidence of the disease (average relative risk; 1.5; P less than 0.01). Infections with the viruses more closely associated with acute otitis media (respiratory syncytial virus, adenovirus, and influenza A or B) were correlated with an increased risk of recurrent disease. Prevention of selected otitis-associated viral infections should reduce the incidence of this disease. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/6281639/A_longitudinal_study_of_respiratory_viruses_and_bacteria_in_the_etiology_of_acute_otitis_media_with_effusion_ L2 - https://www.nejm.org/doi/10.1056/NEJM198206103062301?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -