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Fiberoptic bronchoscopic laser photoradiation for tumor localization in lung cancer.
Chest. 1982 Jul; 82(1):10-4.Chest

Abstract

Hematoporphyrin derivative (HpD) administration and laser photoradiation were combined to clarify the system's clinical applicability in localizing lung cancer tumors. It was used in 16 cases of lung cancer and in one case of severely atypical squamous metaplasia. Tumors were irradiated 48 hours after intravenous injection of 2.0 to 4.0 mg/kg HpD and fluorescence observed. Fluorescence was seen in 13 lung cancer cases in the case of squamous metaplasia, but results were negative in three of the cases of lung cancer. Among the positive cases was one of occult cancer and two invading the trachea, difficult to recognize by conventional fiberoptic bronchoscopy, as was the severely atypical squamous metaplasia. In the three lung cancer cases not fluorescing, the tumors were obscured by blood, necrotic tissue, or normal mucosa. The method holds promise in the diagnosis of malignant tumors. Nevertheless, it needs further refinement and more studies to elucidate definitive differentiation between malignant and severely atypical, nonmalignant tissue.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6282545

Citation

Hayata, Y, et al. "Fiberoptic Bronchoscopic Laser Photoradiation for Tumor Localization in Lung Cancer." Chest, vol. 82, no. 1, 1982, pp. 10-4.
Hayata Y, Kato H, Konaka C, et al. Fiberoptic bronchoscopic laser photoradiation for tumor localization in lung cancer. Chest. 1982;82(1):10-4.
Hayata, Y., Kato, H., Konaka, C., Ono, J., Matsushima, Y., Yoneyama, K., & Nishimiya, K. (1982). Fiberoptic bronchoscopic laser photoradiation for tumor localization in lung cancer. Chest, 82(1), 10-4.
Hayata Y, et al. Fiberoptic Bronchoscopic Laser Photoradiation for Tumor Localization in Lung Cancer. Chest. 1982;82(1):10-4. PubMed PMID: 6282545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fiberoptic bronchoscopic laser photoradiation for tumor localization in lung cancer. AU - Hayata,Y, AU - Kato,H, AU - Konaka,C, AU - Ono,J, AU - Matsushima,Y, AU - Yoneyama,K, AU - Nishimiya,K, PY - 1982/7/1/pubmed PY - 1982/7/1/medline PY - 1982/7/1/entrez SP - 10 EP - 4 JF - Chest JO - Chest VL - 82 IS - 1 N2 - Hematoporphyrin derivative (HpD) administration and laser photoradiation were combined to clarify the system's clinical applicability in localizing lung cancer tumors. It was used in 16 cases of lung cancer and in one case of severely atypical squamous metaplasia. Tumors were irradiated 48 hours after intravenous injection of 2.0 to 4.0 mg/kg HpD and fluorescence observed. Fluorescence was seen in 13 lung cancer cases in the case of squamous metaplasia, but results were negative in three of the cases of lung cancer. Among the positive cases was one of occult cancer and two invading the trachea, difficult to recognize by conventional fiberoptic bronchoscopy, as was the severely atypical squamous metaplasia. In the three lung cancer cases not fluorescing, the tumors were obscured by blood, necrotic tissue, or normal mucosa. The method holds promise in the diagnosis of malignant tumors. Nevertheless, it needs further refinement and more studies to elucidate definitive differentiation between malignant and severely atypical, nonmalignant tissue. SN - 0012-3692 UR - https://www.unboundmedicine.com/medline/citation/6282545/Fiberoptic_bronchoscopic_laser_photoradiation_for_tumor_localization_in_lung_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0012-3692(15)34964-3 DB - PRIME DP - Unbound Medicine ER -