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The dimethylheptyl derivative of (-)-delta 8-tetrahydrocannabinol reduces the turnover rate of gamma-aminobutyric acid in the septum and nucleus accumbens.
Life Sci. 1982 May 24; 30(21):1841-6.LS

Abstract

Accumulating evidence suggests that the cannabinoids exert their action to reduce the turnover rate of acetylcholine in the hippocampus by an action in the septum via inhibitory gamma-butyric acid (GABA) containing interneurons. In the studies presented here administration of the potent dimethylheptyl derivative of (-)-delta-tetrahydrocannabinol, which has previously been shown to reduce the turnover rate of acetylcholine in the hippocampus, reduces the turnover rate of GABA in the septum. A simple model in which cannabinoids transsynaptically activate inhibitory GABAergic septal neurons impinging on cholinergic septal neurons does not explain the data. A more complex model suggesting that inhibitory GABAergic septal interneurons innervate other inhibitory GABAergic septal interneurons has been hypothesized.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

6285114

Citation

Revuelta, A V., et al. "The Dimethylheptyl Derivative of (-)-delta 8-tetrahydrocannabinol Reduces the Turnover Rate of Gamma-aminobutyric Acid in the Septum and Nucleus Accumbens." Life Sciences, vol. 30, no. 21, 1982, pp. 1841-6.
Revuelta AV, Cheney DL, Costa E. The dimethylheptyl derivative of (-)-delta 8-tetrahydrocannabinol reduces the turnover rate of gamma-aminobutyric acid in the septum and nucleus accumbens. Life Sci. 1982;30(21):1841-6.
Revuelta, A. V., Cheney, D. L., & Costa, E. (1982). The dimethylheptyl derivative of (-)-delta 8-tetrahydrocannabinol reduces the turnover rate of gamma-aminobutyric acid in the septum and nucleus accumbens. Life Sciences, 30(21), 1841-6.
Revuelta AV, Cheney DL, Costa E. The Dimethylheptyl Derivative of (-)-delta 8-tetrahydrocannabinol Reduces the Turnover Rate of Gamma-aminobutyric Acid in the Septum and Nucleus Accumbens. Life Sci. 1982 May 24;30(21):1841-6. PubMed PMID: 6285114.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The dimethylheptyl derivative of (-)-delta 8-tetrahydrocannabinol reduces the turnover rate of gamma-aminobutyric acid in the septum and nucleus accumbens. AU - Revuelta,A V, AU - Cheney,D L, AU - Costa,E, PY - 1982/5/24/pubmed PY - 1982/5/24/medline PY - 1982/5/24/entrez SP - 1841 EP - 6 JF - Life sciences JO - Life Sci VL - 30 IS - 21 N2 - Accumulating evidence suggests that the cannabinoids exert their action to reduce the turnover rate of acetylcholine in the hippocampus by an action in the septum via inhibitory gamma-butyric acid (GABA) containing interneurons. In the studies presented here administration of the potent dimethylheptyl derivative of (-)-delta-tetrahydrocannabinol, which has previously been shown to reduce the turnover rate of acetylcholine in the hippocampus, reduces the turnover rate of GABA in the septum. A simple model in which cannabinoids transsynaptically activate inhibitory GABAergic septal neurons impinging on cholinergic septal neurons does not explain the data. A more complex model suggesting that inhibitory GABAergic septal interneurons innervate other inhibitory GABAergic septal interneurons has been hypothesized. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/6285114/The_dimethylheptyl_derivative_of_____delta_8_tetrahydrocannabinol_reduces_the_turnover_rate_of_gamma_aminobutyric_acid_in_the_septum_and_nucleus_accumbens_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0024-3205(82)90322-8 DB - PRIME DP - Unbound Medicine ER -