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Effect of furosemide upon endolymph potassium concentration.
Hear Res. 1982 Jul; 7(2):223-31.HR

Abstract

Chinchillas were anesthetized with ketamine (40 mg/kg i.m.) and endocochlear potential (EP) and potassium concentration in endolymph (Ke+) were determined in control animals and in animals injected with various doses of furosemide (25, 50 or 100 mg/kg i.v.) by means of microelectrodes inserted into scala media. Control EP and Ke+ in the chinchilla were 81.3 +/- 3.8 mV and 158.5 +/- 3.2 mequiv./l, respectively. Following injection of furosemide, a dose-related fall in EP and Ke+ was observed. However, the EP declined much more rapidly than the Ke+, and recovered more quickly than the latter. The recovery of Ke+ tended to lag behind the EP recovery. The debate over whether potassium transport into endolymph and endocochlear potential generation are related or independent events is discussed in the light of recent literature and the present study.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6286585

Citation

Rybak, L P., and T Morizono. "Effect of Furosemide Upon Endolymph Potassium Concentration." Hearing Research, vol. 7, no. 2, 1982, pp. 223-31.
Rybak LP, Morizono T. Effect of furosemide upon endolymph potassium concentration. Hear Res. 1982;7(2):223-31.
Rybak, L. P., & Morizono, T. (1982). Effect of furosemide upon endolymph potassium concentration. Hearing Research, 7(2), 223-31.
Rybak LP, Morizono T. Effect of Furosemide Upon Endolymph Potassium Concentration. Hear Res. 1982;7(2):223-31. PubMed PMID: 6286585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of furosemide upon endolymph potassium concentration. AU - Rybak,L P, AU - Morizono,T, PY - 1982/7/1/pubmed PY - 1982/7/1/medline PY - 1982/7/1/entrez SP - 223 EP - 31 JF - Hearing research JO - Hear Res VL - 7 IS - 2 N2 - Chinchillas were anesthetized with ketamine (40 mg/kg i.m.) and endocochlear potential (EP) and potassium concentration in endolymph (Ke+) were determined in control animals and in animals injected with various doses of furosemide (25, 50 or 100 mg/kg i.v.) by means of microelectrodes inserted into scala media. Control EP and Ke+ in the chinchilla were 81.3 +/- 3.8 mV and 158.5 +/- 3.2 mequiv./l, respectively. Following injection of furosemide, a dose-related fall in EP and Ke+ was observed. However, the EP declined much more rapidly than the Ke+, and recovered more quickly than the latter. The recovery of Ke+ tended to lag behind the EP recovery. The debate over whether potassium transport into endolymph and endocochlear potential generation are related or independent events is discussed in the light of recent literature and the present study. SN - 0378-5955 UR - https://www.unboundmedicine.com/medline/citation/6286585/Effect_of_furosemide_upon_endolymph_potassium_concentration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0378-5955(82)90015-6 DB - PRIME DP - Unbound Medicine ER -