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Protection against ethanol-induced embryonic damage by administering gamma-linolenic and linoleic acids.
Prostaglandins Leukot Med. 1982 Jun; 8(6):641-5.PL

Abstract

Many reports have now confirmed the teratogenic potential of alcohol in humans and in laboratory animals. A characteristic pattern of congenital anomalies is present in infants born to mothers suffering from chronic alcoholism. The pathogenesis of this condition is unclear. Chronic consumption of ethanol causes a depletion of essential fatty acids, partly by blocking gamma-linolenic acid formation and partly by depleting dihomogammalinolenic acid. Whether this action of ethanol on essential fatty acid and prostaglandin metabolism may account for its teratogenic potential was investigated in the rat. Treatment of pregnant rats with ethanol and evening primrose oil (efamol), a rich source of gammalinolenic acid, led to a significant reduction in the embryopathic activity of ethanol.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6287501

Citation

Varma, P K., and T V. Persaud. "Protection Against Ethanol-induced Embryonic Damage By Administering Gamma-linolenic and Linoleic Acids." Prostaglandins, Leukotrienes, and Medicine, vol. 8, no. 6, 1982, pp. 641-5.
Varma PK, Persaud TV. Protection against ethanol-induced embryonic damage by administering gamma-linolenic and linoleic acids. Prostaglandins Leukot Med. 1982;8(6):641-5.
Varma, P. K., & Persaud, T. V. (1982). Protection against ethanol-induced embryonic damage by administering gamma-linolenic and linoleic acids. Prostaglandins, Leukotrienes, and Medicine, 8(6), 641-5.
Varma PK, Persaud TV. Protection Against Ethanol-induced Embryonic Damage By Administering Gamma-linolenic and Linoleic Acids. Prostaglandins Leukot Med. 1982;8(6):641-5. PubMed PMID: 6287501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protection against ethanol-induced embryonic damage by administering gamma-linolenic and linoleic acids. AU - Varma,P K, AU - Persaud,T V, PY - 1982/6/1/pubmed PY - 1982/6/1/medline PY - 1982/6/1/entrez SP - 641 EP - 5 JF - Prostaglandins, leukotrienes, and medicine JO - Prostaglandins Leukot Med VL - 8 IS - 6 N2 - Many reports have now confirmed the teratogenic potential of alcohol in humans and in laboratory animals. A characteristic pattern of congenital anomalies is present in infants born to mothers suffering from chronic alcoholism. The pathogenesis of this condition is unclear. Chronic consumption of ethanol causes a depletion of essential fatty acids, partly by blocking gamma-linolenic acid formation and partly by depleting dihomogammalinolenic acid. Whether this action of ethanol on essential fatty acid and prostaglandin metabolism may account for its teratogenic potential was investigated in the rat. Treatment of pregnant rats with ethanol and evening primrose oil (efamol), a rich source of gammalinolenic acid, led to a significant reduction in the embryopathic activity of ethanol. SN - 0262-1746 UR - https://www.unboundmedicine.com/medline/citation/6287501/Protection_against_ethanol_induced_embryonic_damage_by_administering_gamma_linolenic_and_linoleic_acids_ DB - PRIME DP - Unbound Medicine ER -