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Quantitative analysis for delta 9-THC, 11-hydroxy-delta 9-THC, and 9-carboxy-delta 9-THC in plasma using GC/CI-MS.
NIDA Res Monogr. 1982; 42:99-118.NR

Abstract

A method for quantitative measurement of delta 9-THC concentrations in plasma has been developed and applied to the analysis of more than 2000 samples over the past 4 years. The method includes addition of deuterium-labeled delta 9-THC to the plasma for use as the internal standard, a simple and relatively rapid solvent extraction procedure, formation of the trimethylsilyl derivative, and quantitation by selected ion monitoring using ammonia chemical ionization. A similar procedure has also been developed for simultaneous analysis of delta 9-THC and two of its major metabolites in plasma. The latter procedure requires use of a glass capillary column for assays of plasma samples in which the delta 9-THC concentration is below 10 ng/ml. Sensitivities for both methods permit quantitation of THC and its metabolites at concentrations as low as 0.2 ng in 1-ml plasma samples.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6294528

Citation

Foltz, R L., and B J. Hidy. "Quantitative Analysis for Delta 9-THC, 11-hydroxy-delta 9-THC, and 9-carboxy-delta 9-THC in Plasma Using GC/CI-MS." NIDA Research Monograph, vol. 42, 1982, pp. 99-118.
Foltz RL, Hidy BJ. Quantitative analysis for delta 9-THC, 11-hydroxy-delta 9-THC, and 9-carboxy-delta 9-THC in plasma using GC/CI-MS. NIDA Res Monogr. 1982;42:99-118.
Foltz, R. L., & Hidy, B. J. (1982). Quantitative analysis for delta 9-THC, 11-hydroxy-delta 9-THC, and 9-carboxy-delta 9-THC in plasma using GC/CI-MS. NIDA Research Monograph, 42, 99-118.
Foltz RL, Hidy BJ. Quantitative Analysis for Delta 9-THC, 11-hydroxy-delta 9-THC, and 9-carboxy-delta 9-THC in Plasma Using GC/CI-MS. NIDA Res Monogr. 1982;42:99-118. PubMed PMID: 6294528.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantitative analysis for delta 9-THC, 11-hydroxy-delta 9-THC, and 9-carboxy-delta 9-THC in plasma using GC/CI-MS. AU - Foltz,R L, AU - Hidy,B J, PY - 1982/1/1/pubmed PY - 1982/1/1/medline PY - 1982/1/1/entrez SP - 99 EP - 118 JF - NIDA research monograph JO - NIDA Res Monogr VL - 42 N2 - A method for quantitative measurement of delta 9-THC concentrations in plasma has been developed and applied to the analysis of more than 2000 samples over the past 4 years. The method includes addition of deuterium-labeled delta 9-THC to the plasma for use as the internal standard, a simple and relatively rapid solvent extraction procedure, formation of the trimethylsilyl derivative, and quantitation by selected ion monitoring using ammonia chemical ionization. A similar procedure has also been developed for simultaneous analysis of delta 9-THC and two of its major metabolites in plasma. The latter procedure requires use of a glass capillary column for assays of plasma samples in which the delta 9-THC concentration is below 10 ng/ml. Sensitivities for both methods permit quantitation of THC and its metabolites at concentrations as low as 0.2 ng in 1-ml plasma samples. SN - 1046-9516 UR - https://www.unboundmedicine.com/medline/citation/6294528/Quantitative_analysis_for_delta_9_THC_11_hydroxy_delta_9_THC_and_9_carboxy_delta_9_THC_in_plasma_using_GC/CI_MS_ DB - PRIME DP - Unbound Medicine ER -
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