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Local pulmonary immunity in pigeon breeder's disease. A case study.
Ann Intern Med. 1978 Mar; 88(3):355-8.AIM

Abstract

We studied pulmonary and systemic aspects of the immune response in a patient with pigeon breeder's disease before and after an inhalation challenge with pigeon serum. Macrophage migration inhibition was induced with bronchoalveolar wash cells exposed to both pigeon serum and pigeon dropping extract before but not after challenge. Peripheral blood lymphocytes exposed to these antigens did not induce inhibition of guinea pig peritoneal macrophage migration before challenge. However, after challenge peripheral blood lymphocytes did cause macrophage migration inhibition when exposed to pigeon serum. Both systemic and bronchoalveolar lymphocytes proliferated when exposed to these pigeon antigens in vitro. Our patient represents the first reported case of lymphokine production by pulmonary as well as systemic lymphocytes in hypersensitivity pneumonitis.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

629498

Citation

Schuyler, M R., et al. "Local Pulmonary Immunity in Pigeon Breeder's Disease. a Case Study." Annals of Internal Medicine, vol. 88, no. 3, 1978, pp. 355-8.
Schuyler MR, Thigpen TP, Salvaggio JE. Local pulmonary immunity in pigeon breeder's disease. A case study. Ann Intern Med. 1978;88(3):355-8.
Schuyler, M. R., Thigpen, T. P., & Salvaggio, J. E. (1978). Local pulmonary immunity in pigeon breeder's disease. A case study. Annals of Internal Medicine, 88(3), 355-8.
Schuyler MR, Thigpen TP, Salvaggio JE. Local Pulmonary Immunity in Pigeon Breeder's Disease. a Case Study. Ann Intern Med. 1978;88(3):355-8. PubMed PMID: 629498.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Local pulmonary immunity in pigeon breeder's disease. A case study. AU - Schuyler,M R, AU - Thigpen,T P, AU - Salvaggio,J E, PY - 1978/3/1/pubmed PY - 1978/3/1/medline PY - 1978/3/1/entrez SP - 355 EP - 8 JF - Annals of internal medicine JO - Ann Intern Med VL - 88 IS - 3 N2 - We studied pulmonary and systemic aspects of the immune response in a patient with pigeon breeder's disease before and after an inhalation challenge with pigeon serum. Macrophage migration inhibition was induced with bronchoalveolar wash cells exposed to both pigeon serum and pigeon dropping extract before but not after challenge. Peripheral blood lymphocytes exposed to these antigens did not induce inhibition of guinea pig peritoneal macrophage migration before challenge. However, after challenge peripheral blood lymphocytes did cause macrophage migration inhibition when exposed to pigeon serum. Both systemic and bronchoalveolar lymphocytes proliferated when exposed to these pigeon antigens in vitro. Our patient represents the first reported case of lymphokine production by pulmonary as well as systemic lymphocytes in hypersensitivity pneumonitis. SN - 0003-4819 UR - https://www.unboundmedicine.com/medline/citation/629498/Local_pulmonary_immunity_in_pigeon_breeder's_disease__A_case_study_ L2 - https://www.acpjournals.org/doi/10.7326/0003-4819-88-3-355?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -