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Ankylosing spondylitis and inflammatory bowel disease. III. Clinical characteristics and results of histocompatibility typing (HLA B27) in 50 patients with both ankylosing spondylitis and inflammatory bowel disease.
Ann Rheum Dis. 1978 Feb; 37(1):36-41.AR

Abstract

A study was made, in co-operation with several gastroenterology and rheumatology centres, of the clinical and genetic characteristics (HLA B27) of 50 patients suffering from both inflammatory bowel disease (38 Crohn's disease (CD), 12 ulcerated colitis (UC)) and ankylosing spondylitis (AS), the latter diagnosis being established according to the New York criteria. 20 CD (52.6%) and 8 UC (66.7%) patients were HLA B27 positive. The presence of HLA B27 was studied in relation to clinical parameters, such as first occurrence of symptoms of AS or inflammatory bowel disease (IBD), a history of peripheral arthritis, iridocyclitis, and a positive history of AS or IBD. Our patients were found to have heterogeneous clinical features: on one side of the spectrum a group of cases was distingiushed with the typical characteristics of idiopathic AS, often being HLA B27 positive. On the other side a smaller group of HLA B27 negative patients was observed, with severe intestinal inflammatory pathology, lacking most of the typical clinical features of idiopathic AS ('secondary' form of AS). Finally, between these two extremes a group of patients was found with less pronounced clinical or genetic characteristics. These different clinical and histocompatibility patterns suggest a mixed aetiopathogenesis of AS in IBD patients. Such a 'syndrome' of AS might harbour both idiopathic AS and forms of AS 'secondary' to the intestinal inflammatory pathology.

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Authors

Dekker-Saeys BJ
No affiliation info available
Meuwissen SG
No affiliation info available
Van Den Berg-Loonen EM
No affiliation info available
De Haas WH
No affiliation info available
Meijers KA
No affiliation info available
Tytgat GN
No affiliation info available

MeSH

AdultAgedColitis, UlcerativeCrohn DiseaseFemaleHLA AntigensHumansMaleMiddle AgedRadiographySacroiliac JointSpondylitis, Ankylosing

Pub Type(s)

Journal Article

Language

eng

PubMed ID

629602

Citation

Dekker-Saeys, B J., et al. "Ankylosing Spondylitis and Inflammatory Bowel Disease. III. Clinical Characteristics and Results of Histocompatibility Typing (HLA B27) in 50 Patients With Both Ankylosing Spondylitis and Inflammatory Bowel Disease." Annals of the Rheumatic Diseases, vol. 37, no. 1, 1978, pp. 36-41.
Dekker-Saeys BJ, Meuwissen SG, Van Den Berg-Loonen EM, et al. Ankylosing spondylitis and inflammatory bowel disease. III. Clinical characteristics and results of histocompatibility typing (HLA B27) in 50 patients with both ankylosing spondylitis and inflammatory bowel disease. Ann Rheum Dis. 1978;37(1):36-41.
Dekker-Saeys, B. J., Meuwissen, S. G., Van Den Berg-Loonen, E. M., De Haas, W. H., Meijers, K. A., & Tytgat, G. N. (1978). Ankylosing spondylitis and inflammatory bowel disease. III. Clinical characteristics and results of histocompatibility typing (HLA B27) in 50 patients with both ankylosing spondylitis and inflammatory bowel disease. Annals of the Rheumatic Diseases, 37(1), 36-41.
Dekker-Saeys BJ, et al. Ankylosing Spondylitis and Inflammatory Bowel Disease. III. Clinical Characteristics and Results of Histocompatibility Typing (HLA B27) in 50 Patients With Both Ankylosing Spondylitis and Inflammatory Bowel Disease. Ann Rheum Dis. 1978;37(1):36-41. PubMed PMID: 629602.
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TY - JOUR T1 - Ankylosing spondylitis and inflammatory bowel disease. III. Clinical characteristics and results of histocompatibility typing (HLA B27) in 50 patients with both ankylosing spondylitis and inflammatory bowel disease. AU - Dekker-Saeys,B J, AU - Meuwissen,S G, AU - Van Den Berg-Loonen,E M, AU - De Haas,W H, AU - Meijers,K A, AU - Tytgat,G N, PY - 1978/2/1/pubmed PY - 1978/2/1/medline PY - 1978/2/1/entrez SP - 36 EP - 41 JF - Annals of the rheumatic diseases JO - Ann Rheum Dis VL - 37 IS - 1 N2 - A study was made, in co-operation with several gastroenterology and rheumatology centres, of the clinical and genetic characteristics (HLA B27) of 50 patients suffering from both inflammatory bowel disease (38 Crohn's disease (CD), 12 ulcerated colitis (UC)) and ankylosing spondylitis (AS), the latter diagnosis being established according to the New York criteria. 20 CD (52.6%) and 8 UC (66.7%) patients were HLA B27 positive. The presence of HLA B27 was studied in relation to clinical parameters, such as first occurrence of symptoms of AS or inflammatory bowel disease (IBD), a history of peripheral arthritis, iridocyclitis, and a positive history of AS or IBD. Our patients were found to have heterogeneous clinical features: on one side of the spectrum a group of cases was distingiushed with the typical characteristics of idiopathic AS, often being HLA B27 positive. On the other side a smaller group of HLA B27 negative patients was observed, with severe intestinal inflammatory pathology, lacking most of the typical clinical features of idiopathic AS ('secondary' form of AS). Finally, between these two extremes a group of patients was found with less pronounced clinical or genetic characteristics. These different clinical and histocompatibility patterns suggest a mixed aetiopathogenesis of AS in IBD patients. Such a 'syndrome' of AS might harbour both idiopathic AS and forms of AS 'secondary' to the intestinal inflammatory pathology. SN - 0003-4967 UR - https://www.unboundmedicine.com/medline/citation/629602/Ankylosing_spondylitis_and_inflammatory_bowel_disease__III__Clinical_characteristics_and_results_of_histocompatibility_typing__HLA_B27__in_50_patients_with_both_ankylosing_spondylitis_and_inflammatory_bowel_disease_ L2 - https://ard.bmj.com/lookup/pmidlookup?view=long&pmid=629602 DB - PRIME DP - Unbound Medicine ER -