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Junin virus infection of Callithrix jacchus: pathologic features.
Am J Trop Med Hyg. 1983 Mar; 32(2):417-23.AJ

Abstract

Infection of Callithrix jacchus, a New World primate, with the prototype strain of Junin virus produced a severe disease. The animals developed multifocal hemorrhages and characteristic microscopic lesions such as meningoencephalitis, interstitial pneumonia, lymphocytic depletion of lymphatic tissue, hepatocytic necrosis, and a variable decrease in bone marrow cellularity. High virus concentrations correlated with lesions, and with the presence of viral antigenic determinants as revealed by immunofluorescent methods. With the exception of central nervous system damage, the morphological features and immunohistochemical and viral findings were similar to those recorded in human Argentine hemorrhagic fever.

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Publisher Full Text

Authors

González PH
No affiliation info available
Laguens RP
No affiliation info available
Frigerio MJ
No affiliation info available
Calello MA
No affiliation info available
Weissenbacher MC
No affiliation info available

MeSH

AnimalsArenaviruses, New WorldBrainCallithrixCallitrichinaeFluorescent Antibody TechniqueHemorrhagic Fever, AmericanHumansLiverLungLymph NodesMaleMonkey Diseases

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6301303

Citation

González, P H., et al. "Junin Virus Infection of Callithrix Jacchus: Pathologic Features." The American Journal of Tropical Medicine and Hygiene, vol. 32, no. 2, 1983, pp. 417-23.
González PH, Laguens RP, Frigerio MJ, et al. Junin virus infection of Callithrix jacchus: pathologic features. Am J Trop Med Hyg. 1983;32(2):417-23.
González, P. H., Laguens, R. P., Frigerio, M. J., Calello, M. A., & Weissenbacher, M. C. (1983). Junin virus infection of Callithrix jacchus: pathologic features. The American Journal of Tropical Medicine and Hygiene, 32(2), 417-23.
González PH, et al. Junin Virus Infection of Callithrix Jacchus: Pathologic Features. Am J Trop Med Hyg. 1983;32(2):417-23. PubMed PMID: 6301303.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Junin virus infection of Callithrix jacchus: pathologic features. AU - González,P H, AU - Laguens,R P, AU - Frigerio,M J, AU - Calello,M A, AU - Weissenbacher,M C, PY - 1983/3/1/pubmed PY - 1983/3/1/medline PY - 1983/3/1/entrez SP - 417 EP - 23 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 32 IS - 2 N2 - Infection of Callithrix jacchus, a New World primate, with the prototype strain of Junin virus produced a severe disease. The animals developed multifocal hemorrhages and characteristic microscopic lesions such as meningoencephalitis, interstitial pneumonia, lymphocytic depletion of lymphatic tissue, hepatocytic necrosis, and a variable decrease in bone marrow cellularity. High virus concentrations correlated with lesions, and with the presence of viral antigenic determinants as revealed by immunofluorescent methods. With the exception of central nervous system damage, the morphological features and immunohistochemical and viral findings were similar to those recorded in human Argentine hemorrhagic fever. SN - 0002-9637 UR - https://www.unboundmedicine.com/medline/citation/6301303/Junin_virus_infection_of_Callithrix_jacchus:_pathologic_features_ L2 - https://ajtmh.org/doi/10.4269/ajtmh.1983.32.417 DB - PRIME DP - Unbound Medicine ER -