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Alexander's disease in an adult: clinicopathologic study of a case and review of the literature.
Clin Neuropathol. 1982; 1(3):106-12.CN

Abstract

A case of Alexander's disease in a 39-year-old man is reported. The clinical course was characterized by headaches and cerebellar gait for 6 months. A state of acute unconsciousness followed, lasting 2 days. Subsequently, dysfunction of the lower cranial nerves on the left-side, left-sided motor incoordination, and a right-sided spastic hemiplegia were found. The patient died 49 days after an acute incident of lung embolism. Neuropathologically generalized and focally pronounced Rosenthal fibers in subpial, subependymal, and perivascular regions were found. They were especially predominant in the brain stem and cerebellum. Atypical fibrillary glia, moderate patchy demyelination, and circumscribed cystic necrosis in the brain stem were also observed.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

6301723

Citation

Spalke, G, and H D. Mennel. "Alexander's Disease in an Adult: Clinicopathologic Study of a Case and Review of the Literature." Clinical Neuropathology, vol. 1, no. 3, 1982, pp. 106-12.
Spalke G, Mennel HD. Alexander's disease in an adult: clinicopathologic study of a case and review of the literature. Clin Neuropathol. 1982;1(3):106-12.
Spalke, G., & Mennel, H. D. (1982). Alexander's disease in an adult: clinicopathologic study of a case and review of the literature. Clinical Neuropathology, 1(3), 106-12.
Spalke G, Mennel HD. Alexander's Disease in an Adult: Clinicopathologic Study of a Case and Review of the Literature. Clin Neuropathol. 1982;1(3):106-12. PubMed PMID: 6301723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alexander's disease in an adult: clinicopathologic study of a case and review of the literature. AU - Spalke,G, AU - Mennel,H D, PY - 1982/1/1/pubmed PY - 1982/1/1/medline PY - 1982/1/1/entrez SP - 106 EP - 12 JF - Clinical neuropathology JO - Clin. Neuropathol. VL - 1 IS - 3 N2 - A case of Alexander's disease in a 39-year-old man is reported. The clinical course was characterized by headaches and cerebellar gait for 6 months. A state of acute unconsciousness followed, lasting 2 days. Subsequently, dysfunction of the lower cranial nerves on the left-side, left-sided motor incoordination, and a right-sided spastic hemiplegia were found. The patient died 49 days after an acute incident of lung embolism. Neuropathologically generalized and focally pronounced Rosenthal fibers in subpial, subependymal, and perivascular regions were found. They were especially predominant in the brain stem and cerebellum. Atypical fibrillary glia, moderate patchy demyelination, and circumscribed cystic necrosis in the brain stem were also observed. SN - 0722-5091 UR - https://www.unboundmedicine.com/medline/citation/6301723/Alexander's_disease_in_an_adult:_clinicopathologic_study_of_a_case_and_review_of_the_literature_ DB - PRIME DP - Unbound Medicine ER -