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Chlorpromazine effects upon rabbit lens water and electrolyte balance.
Exp Eye Res. 1983 Apr; 36(4):559-65.EE

Abstract

Chlorpromazine (CPZ) concentrations of 5 x 10(-5)M or greater were found to disrupt lens electrolyte and water balance significantly. Lens sodium and calcium levels increased while potassium decreased. These changes were accompanied by water accumulation. Such effects of CPZ were not dependent upon exposure to ultraviolet light. Electrical measurements revealed that CPZ induced depolarization of the lens potential but little change of overall lens conductance. 86Rb efflux from the lens was unaltered by a 1 hr exposure to CPZ. The active sodium pump in the lens was inhibited by CPZ, as evidenced by a reduction in Na- K-ATPase activity.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6303824

Citation

Wilson, C C., et al. "Chlorpromazine Effects Upon Rabbit Lens Water and Electrolyte Balance." Experimental Eye Research, vol. 36, no. 4, 1983, pp. 559-65.
Wilson CC, Delamere NA, Paterson CA. Chlorpromazine effects upon rabbit lens water and electrolyte balance. Exp Eye Res. 1983;36(4):559-65.
Wilson, C. C., Delamere, N. A., & Paterson, C. A. (1983). Chlorpromazine effects upon rabbit lens water and electrolyte balance. Experimental Eye Research, 36(4), 559-65.
Wilson CC, Delamere NA, Paterson CA. Chlorpromazine Effects Upon Rabbit Lens Water and Electrolyte Balance. Exp Eye Res. 1983;36(4):559-65. PubMed PMID: 6303824.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chlorpromazine effects upon rabbit lens water and electrolyte balance. AU - Wilson,C C, AU - Delamere,N A, AU - Paterson,C A, PY - 1983/4/1/pubmed PY - 1983/4/1/medline PY - 1983/4/1/entrez SP - 559 EP - 65 JF - Experimental eye research JO - Exp Eye Res VL - 36 IS - 4 N2 - Chlorpromazine (CPZ) concentrations of 5 x 10(-5)M or greater were found to disrupt lens electrolyte and water balance significantly. Lens sodium and calcium levels increased while potassium decreased. These changes were accompanied by water accumulation. Such effects of CPZ were not dependent upon exposure to ultraviolet light. Electrical measurements revealed that CPZ induced depolarization of the lens potential but little change of overall lens conductance. 86Rb efflux from the lens was unaltered by a 1 hr exposure to CPZ. The active sodium pump in the lens was inhibited by CPZ, as evidenced by a reduction in Na- K-ATPase activity. SN - 0014-4835 UR - https://www.unboundmedicine.com/medline/citation/6303824/Chlorpromazine_effects_upon_rabbit_lens_water_and_electrolyte_balance_ L2 - https://medlineplus.gov/fluidandelectrolytebalance.html DB - PRIME DP - Unbound Medicine ER -