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[Vitamin D metabolism, regulation, function].
Padiatr Padol 1983; 18(2):131-8PP

Abstract

In a review of the literature metabolism, regulation and function of vitamin D and its active metabolites is discussed. Vitamin D is absorbed from the gut and produced in the skin. 25-hydroxylation takes place in the liver, producing 25-hydroxy-vitamin-D. This metabolite is transferred and hydroxylated in the kidney. The most potent cholecalciferol is 1,25-dihydroxy-vitamin-D. This hydroxylation process is regulated by the need of phosphorus and calcium and by calcicotropic hormones, e. g. parathyroid-hormone. The active cholecalciferols regulate intestinal, renal and osseous handling of calcium and phosphorus by binding to a specific receptor protein. Thus, the control of serum calcium and -phosphate homeostasis by cholecalciferols guarantees adequate supply of these substances for mineralisation. Accordingly, perinatal period and puberty is associated with a marked increase in active vitamin D metabolites.

Authors

No affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

6304595

Citation

Willvonseder, R. "[Vitamin D Metabolism, Regulation, Function]." Padiatrie Und Padologie, vol. 18, no. 2, 1983, pp. 131-8.
Willvonseder R. [Vitamin D metabolism, regulation, function]. Padiatr Padol. 1983;18(2):131-8.
Willvonseder, R. (1983). [Vitamin D metabolism, regulation, function]. Padiatrie Und Padologie, 18(2), pp. 131-8.
Willvonseder R. [Vitamin D Metabolism, Regulation, Function]. Padiatr Padol. 1983;18(2):131-8. PubMed PMID: 6304595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Vitamin D metabolism, regulation, function]. A1 - Willvonseder,R, PY - 1983/1/1/pubmed PY - 1983/1/1/medline PY - 1983/1/1/entrez SP - 131 EP - 8 JF - Padiatrie und Padologie JO - Padiatr Padol VL - 18 IS - 2 N2 - In a review of the literature metabolism, regulation and function of vitamin D and its active metabolites is discussed. Vitamin D is absorbed from the gut and produced in the skin. 25-hydroxylation takes place in the liver, producing 25-hydroxy-vitamin-D. This metabolite is transferred and hydroxylated in the kidney. The most potent cholecalciferol is 1,25-dihydroxy-vitamin-D. This hydroxylation process is regulated by the need of phosphorus and calcium and by calcicotropic hormones, e. g. parathyroid-hormone. The active cholecalciferols regulate intestinal, renal and osseous handling of calcium and phosphorus by binding to a specific receptor protein. Thus, the control of serum calcium and -phosphate homeostasis by cholecalciferols guarantees adequate supply of these substances for mineralisation. Accordingly, perinatal period and puberty is associated with a marked increase in active vitamin D metabolites. SN - 0030-9338 UR - https://www.unboundmedicine.com/medline/citation/6304595/[Vitamin_D_metabolism_regulation_function]_ L2 - https://medlineplus.gov/rickets.html DB - PRIME DP - Unbound Medicine ER -