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Role of estrogens and progesterone in the etiology and prevention of endometrial cancer: review.
Am J Obstet Gynecol. 1983 Jul 15; 146(6):696-707.AJ

Abstract

Our present knowledge of the role of sex steroids in the development as well as the prevention of endometrial cancer is reviewed. Factors which increase the exposure of the uterus to unopposed estrogens, either exogenous or endogenous, are associated with increased risk of endometrial adenocarcinoma. However, there is increasing evidence that progestogens can reverse endometrial hyperplasia and protect against the development of endometrial cancer. The mechanisms to explain the antiestrogenic effects of progestogens include changes in enzyme activity and steroid receptors in endometrial tissue. Postmenopausal women treated with combined estrogen and progestogen have the lowest incidence of endometrial carcinoma. Oral contraceptives containing both estrogen and progestogen in each tablet are protective against adenocarcinoma of the endometrium, while the sequential oral contraceptive pills afforded less protection. The risks and benefits of these hormone therapies are discussed in relation to the etiology and prevention of endometrial cancer.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

6307050

Citation

Gambrell, R D., et al. "Role of Estrogens and Progesterone in the Etiology and Prevention of Endometrial Cancer: Review." American Journal of Obstetrics and Gynecology, vol. 146, no. 6, 1983, pp. 696-707.
Gambrell RD, Bagnell CA, Greenblatt RB. Role of estrogens and progesterone in the etiology and prevention of endometrial cancer: review. Am J Obstet Gynecol. 1983;146(6):696-707.
Gambrell, R. D., Bagnell, C. A., & Greenblatt, R. B. (1983). Role of estrogens and progesterone in the etiology and prevention of endometrial cancer: review. American Journal of Obstetrics and Gynecology, 146(6), 696-707.
Gambrell RD, Bagnell CA, Greenblatt RB. Role of Estrogens and Progesterone in the Etiology and Prevention of Endometrial Cancer: Review. Am J Obstet Gynecol. 1983 Jul 15;146(6):696-707. PubMed PMID: 6307050.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of estrogens and progesterone in the etiology and prevention of endometrial cancer: review. AU - Gambrell,R D,Jr AU - Bagnell,C A, AU - Greenblatt,R B, PY - 1983/7/15/pubmed PY - 2001/3/28/medline PY - 1983/7/15/entrez KW - Biology KW - Body Weight KW - Cancer KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Methods--side effects KW - Delivery Of Health Care KW - Diabetes Mellitus KW - Diseases KW - Endocrine System KW - Endometrial Cancer--etiology KW - Endometrial Effects KW - Endometrium KW - Estrogens--analysis KW - Estrogens--side effects KW - Family Planning KW - Genitalia KW - Genitalia, Female KW - Health KW - Health Services KW - Hormone Receptors KW - Hormones KW - Lipid Metabolic Effects KW - Literature Review KW - Medicine KW - Membrane Proteins KW - Menopause KW - Neoplasms KW - Nulliparity KW - Obesity KW - Oral Contraceptives, Combined KW - Oral Contraceptives, Phasic KW - Oral Contraceptives--side effects KW - Physiology KW - Preventive Medicine KW - Progestational Hormones KW - Progesterone--side effects KW - Reproduction KW - Reproductive Control Agents KW - Socioeconomic Status KW - Urogenital System KW - Uterus SP - 696 EP - 707 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 146 IS - 6 N2 - Our present knowledge of the role of sex steroids in the development as well as the prevention of endometrial cancer is reviewed. Factors which increase the exposure of the uterus to unopposed estrogens, either exogenous or endogenous, are associated with increased risk of endometrial adenocarcinoma. However, there is increasing evidence that progestogens can reverse endometrial hyperplasia and protect against the development of endometrial cancer. The mechanisms to explain the antiestrogenic effects of progestogens include changes in enzyme activity and steroid receptors in endometrial tissue. Postmenopausal women treated with combined estrogen and progestogen have the lowest incidence of endometrial carcinoma. Oral contraceptives containing both estrogen and progestogen in each tablet are protective against adenocarcinoma of the endometrium, while the sequential oral contraceptive pills afforded less protection. The risks and benefits of these hormone therapies are discussed in relation to the etiology and prevention of endometrial cancer. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/6307050/Role_of_estrogens_and_progesterone_in_the_etiology_and_prevention_of_endometrial_cancer:_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0002-9378(83)91014-1 DB - PRIME DP - Unbound Medicine ER -