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Serum lipids and lipoproteins in insulin-dependent diabetic subjects during high-carbohydrate, high-fiber diet.

Abstract

The response of blood glucose and serum lipids and lipoproteins to a high-carbohydrate, high-fiber, low-fat diet was assessed in 10 insulin-dependent diabetic subjects. The diet contained approximately 60% of calories as carbohydrate (CHO) and 20% as fat. The patients were followed for 2 wk in a metabolic ward and subsequently for 4 wk at home without changing insulin dosage. During this 6-wk period, the fasting blood glucose fell from 10.6 +/- 1.1 to 8.9 +/- 1.3 mmol/L (NS); HbA1 fell from 11.7 +/- 0.5 to 11.0 +/- 0.7% (P less than 0.05). Serum total triglyceride and very-low-density lipoprotein levels remained unchanged. After 2 wk in the ward on a high-CHO diet, total cholesterol fell by 15% (P less than 0.01), LDL cholesterol by 16% (P less than 0.001), and HDL cholesterol by 10% (P less than 0.05). The fall of HDL cholesterol was due to a decrease of HDL3 cholesterol only. After the 4-wk home period on a high-CHO diet, the observed lipoprotein changes were reversed. Heparin-releasable adipose tissue LPL activity was not influenced by a high-CHO diet. In conclusion, a high-carbohydrate, high-fiber, low-fat diet did not deteriorate the diabetic control, and it had no unfavorable effects on serum lipids or lipoproteins.

Links

Authors

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Source

Diabetes care 6:3 pg 224-30

MeSH

Adolescent
Adult
Blood Glucose
Cholesterol
Circadian Rhythm
Diabetes Mellitus
Diet, Diabetic
Dietary Carbohydrates
Dietary Fats
Dietary Fiber
Female
Humans
Insulin
Lipids
Lipoproteins
Male
Triglycerides

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6307613

Citation

Taskinen, M R., et al. "Serum Lipids and Lipoproteins in Insulin-dependent Diabetic Subjects During High-carbohydrate, High-fiber Diet." Diabetes Care, vol. 6, no. 3, 1983, pp. 224-30.
Taskinen MR, Nikkilä EA, Ollus A. Serum lipids and lipoproteins in insulin-dependent diabetic subjects during high-carbohydrate, high-fiber diet. Diabetes Care. 1983;6(3):224-30.
Taskinen, M. R., Nikkilä, E. A., & Ollus, A. (1983). Serum lipids and lipoproteins in insulin-dependent diabetic subjects during high-carbohydrate, high-fiber diet. Diabetes Care, 6(3), pp. 224-30.
Taskinen MR, Nikkilä EA, Ollus A. Serum Lipids and Lipoproteins in Insulin-dependent Diabetic Subjects During High-carbohydrate, High-fiber Diet. Diabetes Care. 1983;6(3):224-30. PubMed PMID: 6307613.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum lipids and lipoproteins in insulin-dependent diabetic subjects during high-carbohydrate, high-fiber diet. AU - Taskinen,M R, AU - Nikkilä,E A, AU - Ollus,A, PY - 1983/5/1/pubmed PY - 1983/5/1/medline PY - 1983/5/1/entrez SP - 224 EP - 30 JF - Diabetes care JO - Diabetes Care VL - 6 IS - 3 N2 - The response of blood glucose and serum lipids and lipoproteins to a high-carbohydrate, high-fiber, low-fat diet was assessed in 10 insulin-dependent diabetic subjects. The diet contained approximately 60% of calories as carbohydrate (CHO) and 20% as fat. The patients were followed for 2 wk in a metabolic ward and subsequently for 4 wk at home without changing insulin dosage. During this 6-wk period, the fasting blood glucose fell from 10.6 +/- 1.1 to 8.9 +/- 1.3 mmol/L (NS); HbA1 fell from 11.7 +/- 0.5 to 11.0 +/- 0.7% (P less than 0.05). Serum total triglyceride and very-low-density lipoprotein levels remained unchanged. After 2 wk in the ward on a high-CHO diet, total cholesterol fell by 15% (P less than 0.01), LDL cholesterol by 16% (P less than 0.001), and HDL cholesterol by 10% (P less than 0.05). The fall of HDL cholesterol was due to a decrease of HDL3 cholesterol only. After the 4-wk home period on a high-CHO diet, the observed lipoprotein changes were reversed. Heparin-releasable adipose tissue LPL activity was not influenced by a high-CHO diet. In conclusion, a high-carbohydrate, high-fiber, low-fat diet did not deteriorate the diabetic control, and it had no unfavorable effects on serum lipids or lipoproteins. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/6307613/Serum_lipids_and_lipoproteins_in_insulin_dependent_diabetic_subjects_during_high_carbohydrate_high_fiber_diet_ L2 - https://medlineplus.gov/diabeticdiet.html DB - PRIME DP - Unbound Medicine ER -