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Lens cation transport and permeability changes following exposure to hydrogen peroxide.
Exp Eye Res. 1983 Jul; 37(1):45-53.EE

Abstract

Exposure of the rabbit lens, in vitro, to 10(-3) M-hydrogen peroxide resulted in an increase of the lens sodium, calcium and water content together with a decrease of the lens potassium content. No such changes were observed in the presence of 10(-4) or 10(-5) M-hydrogen peroxide. 10(-3) M-hydrogen peroxide was observed to diminish 86Rb uptake by 32% and to reduce the lens Na+-, K+-ATPase activity by 37%. The lens potential remained ouabain-sensitive after peroxide treatment. These findings suggest that only partial inhibition of the lens sodium pump takes place in the presence of 10(-3) M-hydrogen peroxide. Lens depolarization, increased lens conductance and an increase rate of 86Rb efflux were also observed upon exposure of the lens to 10(-3) M-hydrogen peroxide. Such alterations of 86Rb efflux and electrophysiological parameters indicate that hydrogen peroxide changes the passive permeability of lens membranes.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6307730

Citation

Delamere, N A., et al. "Lens Cation Transport and Permeability Changes Following Exposure to Hydrogen Peroxide." Experimental Eye Research, vol. 37, no. 1, 1983, pp. 45-53.
Delamere NA, Paterson CA, Cotton TR. Lens cation transport and permeability changes following exposure to hydrogen peroxide. Exp Eye Res. 1983;37(1):45-53.
Delamere, N. A., Paterson, C. A., & Cotton, T. R. (1983). Lens cation transport and permeability changes following exposure to hydrogen peroxide. Experimental Eye Research, 37(1), 45-53.
Delamere NA, Paterson CA, Cotton TR. Lens Cation Transport and Permeability Changes Following Exposure to Hydrogen Peroxide. Exp Eye Res. 1983;37(1):45-53. PubMed PMID: 6307730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lens cation transport and permeability changes following exposure to hydrogen peroxide. AU - Delamere,N A, AU - Paterson,C A, AU - Cotton,T R, PY - 1983/7/1/pubmed PY - 1983/7/1/medline PY - 1983/7/1/entrez SP - 45 EP - 53 JF - Experimental eye research JO - Exp Eye Res VL - 37 IS - 1 N2 - Exposure of the rabbit lens, in vitro, to 10(-3) M-hydrogen peroxide resulted in an increase of the lens sodium, calcium and water content together with a decrease of the lens potassium content. No such changes were observed in the presence of 10(-4) or 10(-5) M-hydrogen peroxide. 10(-3) M-hydrogen peroxide was observed to diminish 86Rb uptake by 32% and to reduce the lens Na+-, K+-ATPase activity by 37%. The lens potential remained ouabain-sensitive after peroxide treatment. These findings suggest that only partial inhibition of the lens sodium pump takes place in the presence of 10(-3) M-hydrogen peroxide. Lens depolarization, increased lens conductance and an increase rate of 86Rb efflux were also observed upon exposure of the lens to 10(-3) M-hydrogen peroxide. Such alterations of 86Rb efflux and electrophysiological parameters indicate that hydrogen peroxide changes the passive permeability of lens membranes. SN - 0014-4835 UR - https://www.unboundmedicine.com/medline/citation/6307730/Lens_cation_transport_and_permeability_changes_following_exposure_to_hydrogen_peroxide_ DB - PRIME DP - Unbound Medicine ER -