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Pathophysiologic features of swine dysentery: cyclic nucleotide-independent production of diarrhea.
Am J Vet Res. 1983 Jul; 44(7):1309-16.AJ

Abstract

Net electrolyte and water transport and unidirectional Na+ fluxes were examined in ligated colonic loops of clinically normal pigs and in pigs with swine dysentery (etiologic agent Treponema hyodysenteriae) in the presence or absence of theophylline. In normal pigs, theophylline abolished net Na+ absorption via a reduction in the lumen-to-blood flux, decreased Cl- absorption, and increased HCO3- accumulation in the lumen. In infected pigs, all net ion transport was abolished, with the addition of theophylline producing little effect. The absence of net Na+ absorption in infected pigs was also the result of a decreased lumen-to-blood flux. Seemingly, colonic malabsorption may be the primary transport alteration in swine dysentery. Concentrations of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) were measured in samples of colonic mucosa from normal and infected pigs after in vitro exposure to a Ringer's solution containing 0 or 20 mM theophylline. Basal values of cAMP or cGMP did not increase in infected colonic mucosa. There was a diminished capacity of the infected mucosa to respond to theophylline. Alterations in ion transport in conjunction with measurements of cAMP and cGMP indicated that the pathogenic mechanism(s) in swine dysentery were not similar to those of Salmonella, Shigella, Vibrio cholerae, or Escherichia coli diarrhea.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6309041

Citation

Schmall, L M., et al. "Pathophysiologic Features of Swine Dysentery: Cyclic Nucleotide-independent Production of Diarrhea." American Journal of Veterinary Research, vol. 44, no. 7, 1983, pp. 1309-16.
Schmall LM, Argenzio RA, Whipp SC. Pathophysiologic features of swine dysentery: cyclic nucleotide-independent production of diarrhea. Am J Vet Res. 1983;44(7):1309-16.
Schmall, L. M., Argenzio, R. A., & Whipp, S. C. (1983). Pathophysiologic features of swine dysentery: cyclic nucleotide-independent production of diarrhea. American Journal of Veterinary Research, 44(7), 1309-16.
Schmall LM, Argenzio RA, Whipp SC. Pathophysiologic Features of Swine Dysentery: Cyclic Nucleotide-independent Production of Diarrhea. Am J Vet Res. 1983;44(7):1309-16. PubMed PMID: 6309041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathophysiologic features of swine dysentery: cyclic nucleotide-independent production of diarrhea. AU - Schmall,L M, AU - Argenzio,R A, AU - Whipp,S C, PY - 1983/7/1/pubmed PY - 1983/7/1/medline PY - 1983/7/1/entrez SP - 1309 EP - 16 JF - American journal of veterinary research JO - Am. J. Vet. Res. VL - 44 IS - 7 N2 - Net electrolyte and water transport and unidirectional Na+ fluxes were examined in ligated colonic loops of clinically normal pigs and in pigs with swine dysentery (etiologic agent Treponema hyodysenteriae) in the presence or absence of theophylline. In normal pigs, theophylline abolished net Na+ absorption via a reduction in the lumen-to-blood flux, decreased Cl- absorption, and increased HCO3- accumulation in the lumen. In infected pigs, all net ion transport was abolished, with the addition of theophylline producing little effect. The absence of net Na+ absorption in infected pigs was also the result of a decreased lumen-to-blood flux. Seemingly, colonic malabsorption may be the primary transport alteration in swine dysentery. Concentrations of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) were measured in samples of colonic mucosa from normal and infected pigs after in vitro exposure to a Ringer's solution containing 0 or 20 mM theophylline. Basal values of cAMP or cGMP did not increase in infected colonic mucosa. There was a diminished capacity of the infected mucosa to respond to theophylline. Alterations in ion transport in conjunction with measurements of cAMP and cGMP indicated that the pathogenic mechanism(s) in swine dysentery were not similar to those of Salmonella, Shigella, Vibrio cholerae, or Escherichia coli diarrhea. SN - 0002-9645 UR - https://www.unboundmedicine.com/medline/citation/6309041/Pathophysiologic_features_of_swine_dysentery:_cyclic_nucleotide_independent_production_of_diarrhea_ DB - PRIME DP - Unbound Medicine ER -