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Fish oil administration as a supplement to a corn oil containing diet affects arterial prostacyclin production more than platelet thromboxane formation in the rat.
Prostaglandins. 1983 May; 25(5):693-710.P

Abstract

The administration to male rats of 5 en % fish oil (FO) as supplement to a diet containing 5 en % corn oil (CO), selectively and markedly decreased arterial parameters (6-keto-PGF1 alpha formation and platelet antiaggregatory activity) assessed in isolated aortic segments perfused with autologous platelet rich plasma (PRP). Platelet parameters (ADP-induced aggregation, TxB2 formation in thrombin-stimulated PRP and sensitivity to exogenous PGI2) were instead minimally affected. Eicosapentaenoic acid (EPA, 20:5 n-3) did not accumulate in plasma, platelet and aorta lipids and arachidonic acid (AA, 20:4 n-6) levels declined markedly only in the plasma compartment. When FO was given alone at the same 5 en % level, both arterial and platelet parameters were similarly affected. EPA accumulated in plasma cholesterol esters and was present in appreciable concentrations also in platelets and aortic walls. AA levels declined markedly in plasma lipids and appreciably also in platelet and aorta lipids. It is concluded that a) arterial and platelet parameters are differentially affected by FO administration depending upon the presence of n-6 polyunsaturated fatty acids in the diet, b) 6-keto-PGF1 alpha production by arterial tissue does not seem to be related to changes of PG precursor fatty acid levels in the phospholipid fraction.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

6310702

Citation

Socini, A, et al. "Fish Oil Administration as a Supplement to a Corn Oil Containing Diet Affects Arterial Prostacyclin Production More Than Platelet Thromboxane Formation in the Rat." Prostaglandins, vol. 25, no. 5, 1983, pp. 693-710.
Socini A, Galli C, Colombo C, et al. Fish oil administration as a supplement to a corn oil containing diet affects arterial prostacyclin production more than platelet thromboxane formation in the rat. Prostaglandins. 1983;25(5):693-710.
Socini, A., Galli, C., Colombo, C., & Tremoli, E. (1983). Fish oil administration as a supplement to a corn oil containing diet affects arterial prostacyclin production more than platelet thromboxane formation in the rat. Prostaglandins, 25(5), 693-710.
Socini A, et al. Fish Oil Administration as a Supplement to a Corn Oil Containing Diet Affects Arterial Prostacyclin Production More Than Platelet Thromboxane Formation in the Rat. Prostaglandins. 1983;25(5):693-710. PubMed PMID: 6310702.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fish oil administration as a supplement to a corn oil containing diet affects arterial prostacyclin production more than platelet thromboxane formation in the rat. AU - Socini,A, AU - Galli,C, AU - Colombo,C, AU - Tremoli,E, PY - 1983/5/1/pubmed PY - 1983/5/1/medline PY - 1983/5/1/entrez SP - 693 EP - 710 JF - Prostaglandins JO - Prostaglandins VL - 25 IS - 5 N2 - The administration to male rats of 5 en % fish oil (FO) as supplement to a diet containing 5 en % corn oil (CO), selectively and markedly decreased arterial parameters (6-keto-PGF1 alpha formation and platelet antiaggregatory activity) assessed in isolated aortic segments perfused with autologous platelet rich plasma (PRP). Platelet parameters (ADP-induced aggregation, TxB2 formation in thrombin-stimulated PRP and sensitivity to exogenous PGI2) were instead minimally affected. Eicosapentaenoic acid (EPA, 20:5 n-3) did not accumulate in plasma, platelet and aorta lipids and arachidonic acid (AA, 20:4 n-6) levels declined markedly only in the plasma compartment. When FO was given alone at the same 5 en % level, both arterial and platelet parameters were similarly affected. EPA accumulated in plasma cholesterol esters and was present in appreciable concentrations also in platelets and aortic walls. AA levels declined markedly in plasma lipids and appreciably also in platelet and aorta lipids. It is concluded that a) arterial and platelet parameters are differentially affected by FO administration depending upon the presence of n-6 polyunsaturated fatty acids in the diet, b) 6-keto-PGF1 alpha production by arterial tissue does not seem to be related to changes of PG precursor fatty acid levels in the phospholipid fraction. SN - 0090-6980 UR - https://www.unboundmedicine.com/medline/citation/6310702/Fish_oil_administration_as_a_supplement_to_a_corn_oil_containing_diet_affects_arterial_prostacyclin_production_more_than_platelet_thromboxane_formation_in_the_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0090-6980(83)90123-5 DB - PRIME DP - Unbound Medicine ER -