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Effect of dietary fats on the delta 6- and delta 5-desaturation of fatty acids in rat liver microsomes.
Br J Nutr. 1983 Nov; 50(3):749-56.BJ

Abstract

Rats were given diets containing (% dietary energy): 46 arachis oil (AO), 36 partially-hydrogenated arachis oil (HAO) + 10 AO, 36 partially-hydrogenated marine oil (HMO) + 10 AO, or 46 of a combination of rape-seed oils high and low in erucic acid (RSO + LERSO). In the liver microsomes the content of arachidonic acid (20:4 omega 6) was reduced in the groups given HAO + AO and HMO + AO. The rates of delta 6-desaturation of linoleic acid into gamma-linolenic acid (18:3 omega 6) and of delta 5-desaturation of dihomo-gamma-linolenic acid into arachidonic acid were studied in vitro at two substrate levels: a high substrate level reflecting maximal microsomal desaturase activity in rat liver and a low substrate level reflecting desaturase activity under physiological conditions. Dietary HAO, rich in 18:1 isomers, suppressed the delta 6-desaturase activity but not the delta 5-desaturase activity. Dietary HMO, rich in 18:1, 20:1 and 22:1 isomers, reduced both delta 6- and delta 5-desaturase activities.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6315055

Citation

Kirstein, D, et al. "Effect of Dietary Fats On the Delta 6- and Delta 5-desaturation of Fatty Acids in Rat Liver Microsomes." The British Journal of Nutrition, vol. 50, no. 3, 1983, pp. 749-56.
Kirstein D, Høy CE, Hølmer G. Effect of dietary fats on the delta 6- and delta 5-desaturation of fatty acids in rat liver microsomes. Br J Nutr. 1983;50(3):749-56.
Kirstein, D., Høy, C. E., & Hølmer, G. (1983). Effect of dietary fats on the delta 6- and delta 5-desaturation of fatty acids in rat liver microsomes. The British Journal of Nutrition, 50(3), 749-56.
Kirstein D, Høy CE, Hølmer G. Effect of Dietary Fats On the Delta 6- and Delta 5-desaturation of Fatty Acids in Rat Liver Microsomes. Br J Nutr. 1983;50(3):749-56. PubMed PMID: 6315055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of dietary fats on the delta 6- and delta 5-desaturation of fatty acids in rat liver microsomes. AU - Kirstein,D, AU - Høy,C E, AU - Hølmer,G, PY - 1983/11/1/pubmed PY - 1983/11/1/medline PY - 1983/11/1/entrez SP - 749 EP - 56 JF - The British journal of nutrition JO - Br J Nutr VL - 50 IS - 3 N2 - Rats were given diets containing (% dietary energy): 46 arachis oil (AO), 36 partially-hydrogenated arachis oil (HAO) + 10 AO, 36 partially-hydrogenated marine oil (HMO) + 10 AO, or 46 of a combination of rape-seed oils high and low in erucic acid (RSO + LERSO). In the liver microsomes the content of arachidonic acid (20:4 omega 6) was reduced in the groups given HAO + AO and HMO + AO. The rates of delta 6-desaturation of linoleic acid into gamma-linolenic acid (18:3 omega 6) and of delta 5-desaturation of dihomo-gamma-linolenic acid into arachidonic acid were studied in vitro at two substrate levels: a high substrate level reflecting maximal microsomal desaturase activity in rat liver and a low substrate level reflecting desaturase activity under physiological conditions. Dietary HAO, rich in 18:1 isomers, suppressed the delta 6-desaturase activity but not the delta 5-desaturase activity. Dietary HMO, rich in 18:1, 20:1 and 22:1 isomers, reduced both delta 6- and delta 5-desaturase activities. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/6315055/Effect_of_dietary_fats_on_the_delta_6__and_delta_5_desaturation_of_fatty_acids_in_rat_liver_microsomes_ L2 - https://www.cambridge.org/core/product/identifier/S0007114583001506/type/journal_article DB - PRIME DP - Unbound Medicine ER -