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Responses of human skin to intradermal injection of leukotrienes C4, D4 and B4.
Br J Pharmacol. 1983 Nov; 80(3):497-502.BJ

Abstract

The ability of intradermally injected leukotrienes C4 (LTC4), LTD4 and LTB4 to produce inflammatory changes in human skin alone and in combination with prostaglandin E2 (PGE2) has been investigated. LTC4 and D4 (0.012-0.38 nmol) caused dose-related erythema and wealing. No evidence of synergism between PGE2 and LTC4 or LTD4 was detected, although only single dose combinations were studied. LTB4 (0.15-1.5 nmol) caused areas of induration which persisted for more than 4 h and which showed perivascular neutrophil infiltrates on histological examination. Only slight synergism between PGE2 and LTB4 was found. It was concluded that these pro-inflammatory properties of LTC4, LTD4 and LTB4 are consistent with their proposed roles as mediators of inflammation in the skin and other tissues.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6315118

Citation

Camp, R D., et al. "Responses of Human Skin to Intradermal Injection of Leukotrienes C4, D4 and B4." British Journal of Pharmacology, vol. 80, no. 3, 1983, pp. 497-502.
Camp RD, Coutts AA, Greaves MW, et al. Responses of human skin to intradermal injection of leukotrienes C4, D4 and B4. Br J Pharmacol. 1983;80(3):497-502.
Camp, R. D., Coutts, A. A., Greaves, M. W., Kay, A. B., & Walport, M. J. (1983). Responses of human skin to intradermal injection of leukotrienes C4, D4 and B4. British Journal of Pharmacology, 80(3), 497-502.
Camp RD, et al. Responses of Human Skin to Intradermal Injection of Leukotrienes C4, D4 and B4. Br J Pharmacol. 1983;80(3):497-502. PubMed PMID: 6315118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Responses of human skin to intradermal injection of leukotrienes C4, D4 and B4. AU - Camp,R D, AU - Coutts,A A, AU - Greaves,M W, AU - Kay,A B, AU - Walport,M J, PY - 1983/11/1/pubmed PY - 1983/11/1/medline PY - 1983/11/1/entrez SP - 497 EP - 502 JF - British journal of pharmacology JO - Br J Pharmacol VL - 80 IS - 3 N2 - The ability of intradermally injected leukotrienes C4 (LTC4), LTD4 and LTB4 to produce inflammatory changes in human skin alone and in combination with prostaglandin E2 (PGE2) has been investigated. LTC4 and D4 (0.012-0.38 nmol) caused dose-related erythema and wealing. No evidence of synergism between PGE2 and LTC4 or LTD4 was detected, although only single dose combinations were studied. LTB4 (0.15-1.5 nmol) caused areas of induration which persisted for more than 4 h and which showed perivascular neutrophil infiltrates on histological examination. Only slight synergism between PGE2 and LTB4 was found. It was concluded that these pro-inflammatory properties of LTC4, LTD4 and LTB4 are consistent with their proposed roles as mediators of inflammation in the skin and other tissues. SN - 0007-1188 UR - https://www.unboundmedicine.com/medline/citation/6315118/Responses_of_human_skin_to_intradermal_injection_of_leukotrienes_C4_D4_and_B4_ DB - PRIME DP - Unbound Medicine ER -