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Acyl group distributions in tissue lipids of rats fed evening primrose oil (gamma -linolenic plus linoleic acid) or soybean oil (alpha-linolenic plus linoleic acid).
Lipids. 1983 Nov; 18(11):760-71.L

Abstract

Three groups of rats were fed diets with either 10 weight percent (wt%) of evening primrose oil, safflower oil or soybean oil for 11 weeks. Diets contained 7.1 wt% linoleic acid + 0.8 wt% gamma-linolenic acid, 7.6 wt% linoleic acid, or 5.3 wt% linoleic acid + 0.7 wt% alpha-linolenic acid, respectively. In liver mitochondria as well as in heart, dietary gamma-linolenic acid did not affect the fatty acid profiles of phosphatidylcholines (PC), phosphatidylethanolamines (PE) or cardiolipins (CL), whereas dietary alpha-linolenic acid caused an increased formation of (n-3) polyunsaturated fatty acids (PUFA). The liver delta 6- and delta 5-desaturase activities determined in vitro were not affected by the dietary fats. In brain PE, which are rich in C22- and C20-(n-3) PUFA, as well as in testes PC and PE, which are rich in (n-6) PUFA, no effects were found from a partial replacement of dietary linoleic acid with gamma-linolenic acid or alpha-linolenic acid. In kidney PC, PE, phosphatidylinositol (PI) and CL, 20:3(n-6) was moderately elevated to ca. 1% following intake of gamma-linolenic acid, whereas partial replacement of linoleic acid with alpha-linolenic acid was followed by increased deposition of 22:6(n-3) in PC and PE of testes and kidney. Thus, no general effect of evening primrose oil on the content of (n-6) PUFA in rat tissue phospholipids was observed, whereas a significant incorporation of gamma-linolenic acid into liver and adipose tissue triglycerides was found.

Authors

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Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6318009

Citation

Høy, C E., et al. "Acyl Group Distributions in Tissue Lipids of Rats Fed Evening Primrose Oil (gamma -linolenic Plus Linoleic Acid) or Soybean Oil (alpha-linolenic Plus Linoleic Acid)." Lipids, vol. 18, no. 11, 1983, pp. 760-71.
Høy CE, Hølmer G, Kaur N, et al. Acyl group distributions in tissue lipids of rats fed evening primrose oil (gamma -linolenic plus linoleic acid) or soybean oil (alpha-linolenic plus linoleic acid). Lipids. 1983;18(11):760-71.
Høy, C. E., Hølmer, G., Kaur, N., Byrjalsen, I., & Kirstein, D. (1983). Acyl group distributions in tissue lipids of rats fed evening primrose oil (gamma -linolenic plus linoleic acid) or soybean oil (alpha-linolenic plus linoleic acid). Lipids, 18(11), 760-71.
Høy CE, et al. Acyl Group Distributions in Tissue Lipids of Rats Fed Evening Primrose Oil (gamma -linolenic Plus Linoleic Acid) or Soybean Oil (alpha-linolenic Plus Linoleic Acid). Lipids. 1983;18(11):760-71. PubMed PMID: 6318009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acyl group distributions in tissue lipids of rats fed evening primrose oil (gamma -linolenic plus linoleic acid) or soybean oil (alpha-linolenic plus linoleic acid). AU - Høy,C E, AU - Hølmer,G, AU - Kaur,N, AU - Byrjalsen,I, AU - Kirstein,D, PY - 1983/11/1/pubmed PY - 1983/11/1/medline PY - 1983/11/1/entrez SP - 760 EP - 71 JF - Lipids JO - Lipids VL - 18 IS - 11 N2 - Three groups of rats were fed diets with either 10 weight percent (wt%) of evening primrose oil, safflower oil or soybean oil for 11 weeks. Diets contained 7.1 wt% linoleic acid + 0.8 wt% gamma-linolenic acid, 7.6 wt% linoleic acid, or 5.3 wt% linoleic acid + 0.7 wt% alpha-linolenic acid, respectively. In liver mitochondria as well as in heart, dietary gamma-linolenic acid did not affect the fatty acid profiles of phosphatidylcholines (PC), phosphatidylethanolamines (PE) or cardiolipins (CL), whereas dietary alpha-linolenic acid caused an increased formation of (n-3) polyunsaturated fatty acids (PUFA). The liver delta 6- and delta 5-desaturase activities determined in vitro were not affected by the dietary fats. In brain PE, which are rich in C22- and C20-(n-3) PUFA, as well as in testes PC and PE, which are rich in (n-6) PUFA, no effects were found from a partial replacement of dietary linoleic acid with gamma-linolenic acid or alpha-linolenic acid. In kidney PC, PE, phosphatidylinositol (PI) and CL, 20:3(n-6) was moderately elevated to ca. 1% following intake of gamma-linolenic acid, whereas partial replacement of linoleic acid with alpha-linolenic acid was followed by increased deposition of 22:6(n-3) in PC and PE of testes and kidney. Thus, no general effect of evening primrose oil on the content of (n-6) PUFA in rat tissue phospholipids was observed, whereas a significant incorporation of gamma-linolenic acid into liver and adipose tissue triglycerides was found. SN - 0024-4201 UR - https://www.unboundmedicine.com/medline/citation/6318009/Acyl_group_distributions_in_tissue_lipids_of_rats_fed_evening_primrose_oil__gamma__linolenic_plus_linoleic_acid__or_soybean_oil__alpha_linolenic_plus_linoleic_acid__ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0024-4201&date=1983&volume=18&issue=11&spage=760 DB - PRIME DP - Unbound Medicine ER -