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Relationships between several pharmacokinetic parameters and psychometric indices of subjective effects of delta 9-tetrahydrocannabinol in man.
Eur J Clin Pharmacol. 1983; 25(5):633-7.EJ

Abstract

This study explored the relationships in man between various pharmacological effect of delta 9-tetrahydrocannabinol (THC), plasma THC concentration, and pharmacokinetic parameters of THC. Three male and three female experienced marihuana users smoked two standard marihuana cigarettes. The relationships between heart rate, subjective "high" rating, Linear Mood Scale factors, and plasma THC concentration were assessed. Significant correlations were observed between various Linear Mood Scale factors and pharmacokinetic parameters reflecting the magnitude of drug intake and the degree of temporal dissociation between the time courses of plasma THC concentration and pharmacological effects (tachycardiac effect, "high"). In particular, the disturbed/weird and sensitive/aware mood factors correlated positively with pharmacokinetic measures of drug intake and time lag to effect. A more reliable index of intoxication with THC may be provided by the global subjective "high" rating, rather than other ratings more specific for particular moods.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6319149

Citation

Miller, L L., et al. "Relationships Between Several Pharmacokinetic Parameters and Psychometric Indices of Subjective Effects of Delta 9-tetrahydrocannabinol in Man." European Journal of Clinical Pharmacology, vol. 25, no. 5, 1983, pp. 633-7.
Miller LL, Cocchetto DM, Perez-Reyes M. Relationships between several pharmacokinetic parameters and psychometric indices of subjective effects of delta 9-tetrahydrocannabinol in man. Eur J Clin Pharmacol. 1983;25(5):633-7.
Miller, L. L., Cocchetto, D. M., & Perez-Reyes, M. (1983). Relationships between several pharmacokinetic parameters and psychometric indices of subjective effects of delta 9-tetrahydrocannabinol in man. European Journal of Clinical Pharmacology, 25(5), 633-7.
Miller LL, Cocchetto DM, Perez-Reyes M. Relationships Between Several Pharmacokinetic Parameters and Psychometric Indices of Subjective Effects of Delta 9-tetrahydrocannabinol in Man. Eur J Clin Pharmacol. 1983;25(5):633-7. PubMed PMID: 6319149.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationships between several pharmacokinetic parameters and psychometric indices of subjective effects of delta 9-tetrahydrocannabinol in man. AU - Miller,L L, AU - Cocchetto,D M, AU - Perez-Reyes,M, PY - 1983/1/1/pubmed PY - 1983/1/1/medline PY - 1983/1/1/entrez SP - 633 EP - 7 JF - European journal of clinical pharmacology JO - Eur J Clin Pharmacol VL - 25 IS - 5 N2 - This study explored the relationships in man between various pharmacological effect of delta 9-tetrahydrocannabinol (THC), plasma THC concentration, and pharmacokinetic parameters of THC. Three male and three female experienced marihuana users smoked two standard marihuana cigarettes. The relationships between heart rate, subjective "high" rating, Linear Mood Scale factors, and plasma THC concentration were assessed. Significant correlations were observed between various Linear Mood Scale factors and pharmacokinetic parameters reflecting the magnitude of drug intake and the degree of temporal dissociation between the time courses of plasma THC concentration and pharmacological effects (tachycardiac effect, "high"). In particular, the disturbed/weird and sensitive/aware mood factors correlated positively with pharmacokinetic measures of drug intake and time lag to effect. A more reliable index of intoxication with THC may be provided by the global subjective "high" rating, rather than other ratings more specific for particular moods. SN - 0031-6970 UR - https://www.unboundmedicine.com/medline/citation/6319149/Relationships_between_several_pharmacokinetic_parameters_and_psychometric_indices_of_subjective_effects_of_delta_9_tetrahydrocannabinol_in_man_ L2 - https://dx.doi.org/10.1007/BF00542351 DB - PRIME DP - Unbound Medicine ER -