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Some effects of linoleic acid and gamma-linolenic acid on the proliferation of human hepatoma cells in culture.
S Afr Med J. 1984 Apr 14; 65(15):607-12.SA

Abstract

In previous communications the growth-suppressive effect of gamma-linolenic acid (GLA) dissolved in sodium carbonate in the culture media of malignant cells has been reported. In this study we show that linoleic acid (LA), the fatty acid precursor of GLA, had no growth-suppressive effect on human hepatoma cells in culture while a similar concentration of GLA suppressed malignant cell growth in culture by 69% after 10 days. This growth-suppressive effect must therefore be seen as an effect of GLA and not as a 'soap' effect. It has also been shown that the growth rate of human hepatoma cells in culture to which GLA was added daily for 5 consecutive days remained suppressed after the withdrawal of GLA from the growth medium for a further 5-day period. The striking difference between GLA and LA as regards growth suppression of human hepatoma cells in culture appears to imply a metabolic block in the hepatoma cells, involving the enzyme delta-6-desaturase, in the conversion of LA to GLA and thence via dihomo-gamma-linolenic acid to the prostaglandins of the 1 series.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6324395

Citation

Booyens, J, et al. "Some Effects of Linoleic Acid and Gamma-linolenic Acid On the Proliferation of Human Hepatoma Cells in Culture." South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde, vol. 65, no. 15, 1984, pp. 607-12.
Booyens J, Dippenaar N, Fabbri D, et al. Some effects of linoleic acid and gamma-linolenic acid on the proliferation of human hepatoma cells in culture. S Afr Med J. 1984;65(15):607-12.
Booyens, J., Dippenaar, N., Fabbri, D., Engelbrecht, P., Louwrens, C. C., & Katzeff, I. E. (1984). Some effects of linoleic acid and gamma-linolenic acid on the proliferation of human hepatoma cells in culture. South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde, 65(15), 607-12.
Booyens J, et al. Some Effects of Linoleic Acid and Gamma-linolenic Acid On the Proliferation of Human Hepatoma Cells in Culture. S Afr Med J. 1984 Apr 14;65(15):607-12. PubMed PMID: 6324395.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Some effects of linoleic acid and gamma-linolenic acid on the proliferation of human hepatoma cells in culture. AU - Booyens,J, AU - Dippenaar,N, AU - Fabbri,D, AU - Engelbrecht,P, AU - Louwrens,C C, AU - Katzeff,I E, PY - 1984/4/14/pubmed PY - 1984/4/14/medline PY - 1984/4/14/entrez SP - 607 EP - 12 JF - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde JO - S Afr Med J VL - 65 IS - 15 N2 - In previous communications the growth-suppressive effect of gamma-linolenic acid (GLA) dissolved in sodium carbonate in the culture media of malignant cells has been reported. In this study we show that linoleic acid (LA), the fatty acid precursor of GLA, had no growth-suppressive effect on human hepatoma cells in culture while a similar concentration of GLA suppressed malignant cell growth in culture by 69% after 10 days. This growth-suppressive effect must therefore be seen as an effect of GLA and not as a 'soap' effect. It has also been shown that the growth rate of human hepatoma cells in culture to which GLA was added daily for 5 consecutive days remained suppressed after the withdrawal of GLA from the growth medium for a further 5-day period. The striking difference between GLA and LA as regards growth suppression of human hepatoma cells in culture appears to imply a metabolic block in the hepatoma cells, involving the enzyme delta-6-desaturase, in the conversion of LA to GLA and thence via dihomo-gamma-linolenic acid to the prostaglandins of the 1 series. SN - 0256-9574 UR - https://www.unboundmedicine.com/medline/citation/6324395/Some_effects_of_linoleic_acid_and_gamma_linolenic_acid_on_the_proliferation_of_human_hepatoma_cells_in_culture_ L2 - https://medlineplus.gov/livercancer.html DB - PRIME DP - Unbound Medicine ER -