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Concurrent Cushing's and Zollinger-Ellison syndromes in a patient with islet cell carcinoma. Case report and review of the literature.
Am J Med. 1984 Apr; 76(4):729-33.AJ

Abstract

This report documents the simultaneous occurrence of Cushing's and Zollinger-Ellison syndromes in a patient with islet cell carcinoma. The clinical concurrence of these two syndromes has been recorded in only three previous case studies, while three other case reports record evidence suggesting the presence of both gastrin and ACTH within the tumor but without clinical sequelae. In the present report, evidence based on multiple clinical and biochemical data supports the concept that both syndromes are a result of "ectopic" hormone production by the tumor.

Authors

Lyons DF
No affiliation info available
Eisen BR
No affiliation info available
Clark MR
No affiliation info available
Pysher TJ
No affiliation info available
Welsh JD
No affiliation info available
Kem DC
No affiliation info available

MeSH

ACTH Syndrome, EctopicAdenoma, Islet CellAdultAgedCushing SyndromeFemaleHumansMaleMiddle AgedPancreatic NeoplasmsParaneoplastic Endocrine SyndromesZollinger-Ellison Syndrome

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

6324590

Citation

Lyons, D F., et al. "Concurrent Cushing's and Zollinger-Ellison Syndromes in a Patient With Islet Cell Carcinoma. Case Report and Review of the Literature." The American Journal of Medicine, vol. 76, no. 4, 1984, pp. 729-33.
Lyons DF, Eisen BR, Clark MR, et al. Concurrent Cushing's and Zollinger-Ellison syndromes in a patient with islet cell carcinoma. Case report and review of the literature. Am J Med. 1984;76(4):729-33.
Lyons, D. F., Eisen, B. R., Clark, M. R., Pysher, T. J., Welsh, J. D., & Kem, D. C. (1984). Concurrent Cushing's and Zollinger-Ellison syndromes in a patient with islet cell carcinoma. Case report and review of the literature. The American Journal of Medicine, 76(4), 729-33.
Lyons DF, et al. Concurrent Cushing's and Zollinger-Ellison Syndromes in a Patient With Islet Cell Carcinoma. Case Report and Review of the Literature. Am J Med. 1984;76(4):729-33. PubMed PMID: 6324590.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Concurrent Cushing's and Zollinger-Ellison syndromes in a patient with islet cell carcinoma. Case report and review of the literature. AU - Lyons,D F, AU - Eisen,B R, AU - Clark,M R, AU - Pysher,T J, AU - Welsh,J D, AU - Kem,D C, PY - 1984/4/1/pubmed PY - 1984/4/1/medline PY - 1984/4/1/entrez SP - 729 EP - 33 JF - The American journal of medicine JO - Am J Med VL - 76 IS - 4 N2 - This report documents the simultaneous occurrence of Cushing's and Zollinger-Ellison syndromes in a patient with islet cell carcinoma. The clinical concurrence of these two syndromes has been recorded in only three previous case studies, while three other case reports record evidence suggesting the presence of both gastrin and ACTH within the tumor but without clinical sequelae. In the present report, evidence based on multiple clinical and biochemical data supports the concept that both syndromes are a result of "ectopic" hormone production by the tumor. SN - 0002-9343 UR - https://www.unboundmedicine.com/medline/citation/6324590/Concurrent_Cushing's_and_Zollinger_Ellison_syndromes_in_a_patient_with_islet_cell_carcinoma__Case_report_and_review_of_the_literature_ DB - PRIME DP - Unbound Medicine ER -