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Transplacental infection in guinea pigs inoculated with an attenuated strain of Junin virus.
Intervirology. 1984; 21(3):178-80.I

Abstract

Transplacental infection by the attenuated XJC13 strain of Junin virus (JV) in the guinea pig model was evaluated. 5 pregnant guinea pigs were infected intramuscularly at 45 +/- 3 days of pregnancy. 4 animals were killed at 14 days postinfection (p.i.), and 1 was sacrificed at 137 days p.i. at the end of its second pregnancy. Evidence of JV was obtained by Vero cell cocultivation in all 14 fetuses harvested (brain and/or spleen) and in 10 of 11 placentas. The results strongly suggest that the attenuated JV strain infected the fetus by the transplacental route, as previously demonstrated for the pathogenic XJ strain. Despite limited sampling, the acute as well as the chronic stage proved viable.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6327563

Citation

Boxaca, M C., et al. "Transplacental Infection in Guinea Pigs Inoculated With an Attenuated Strain of Junin Virus." Intervirology, vol. 21, no. 3, 1984, pp. 178-80.
Boxaca MC, Gómez MM, Berría MI, et al. Transplacental infection in guinea pigs inoculated with an attenuated strain of Junin virus. Intervirology. 1984;21(3):178-80.
Boxaca, M. C., Gómez, M. M., Berría, M. I., & Iácono, R. F. (1984). Transplacental infection in guinea pigs inoculated with an attenuated strain of Junin virus. Intervirology, 21(3), 178-80.
Boxaca MC, et al. Transplacental Infection in Guinea Pigs Inoculated With an Attenuated Strain of Junin Virus. Intervirology. 1984;21(3):178-80. PubMed PMID: 6327563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transplacental infection in guinea pigs inoculated with an attenuated strain of Junin virus. AU - Boxaca,M C, AU - Gómez,M M, AU - Berría,M I, AU - Iácono,R F, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 178 EP - 80 JF - Intervirology JO - Intervirology VL - 21 IS - 3 N2 - Transplacental infection by the attenuated XJC13 strain of Junin virus (JV) in the guinea pig model was evaluated. 5 pregnant guinea pigs were infected intramuscularly at 45 +/- 3 days of pregnancy. 4 animals were killed at 14 days postinfection (p.i.), and 1 was sacrificed at 137 days p.i. at the end of its second pregnancy. Evidence of JV was obtained by Vero cell cocultivation in all 14 fetuses harvested (brain and/or spleen) and in 10 of 11 placentas. The results strongly suggest that the attenuated JV strain infected the fetus by the transplacental route, as previously demonstrated for the pathogenic XJ strain. Despite limited sampling, the acute as well as the chronic stage proved viable. SN - 0300-5526 UR - https://www.unboundmedicine.com/medline/citation/6327563/Transplacental_infection_in_guinea_pigs_inoculated_with_an_attenuated_strain_of_Junin_virus_ L2 - https://www.karger.com?DOI=10.1159/000149517 DB - PRIME DP - Unbound Medicine ER -