Tags

Type your tag names separated by a space and hit enter

Age-dependent alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of spontaneously hypertensive rats.
Prostaglandins. 1984 Mar; 27(3):375-90.P

Abstract

The lipid content as well as the fatty acid pattern of triglycerides, free fatty acids (FFA), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were estimated in renal cortex and medulla of spontaneously hypertensive rats (SHR) and normotensive Wistar rats (WR) at 4, 8, 26 and 52 weeks of age. In general, the level of triglycerides in renal medulla appeared higher when compared with the cortex. On the other hand, PC and PE, increasing with age, were usually higher in the cortex. A decreased percentage of linoleic acid (LA) in triglycerides, of arachidonic acid (AA) in PC and of eicosapentaenoic acid (EPA) in triglycerides, FFA, PC and PE could be found in the kidneys of SHR at 8 weeks of age, i.e. during the development of hypertension. This was accompanied with a rise of AA in FFA of SHR at 8 weeks of age, which occurred with delay in WR (at 26 weeks of age). From the data presented it can be concluded that systematic alterations in the availability of individual polyunsaturated fatty acids (PUFA) in various renal lipids might be related to the onset of hypertension in SHR which should be elucidated in more detail.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6328578

Citation

Singer, P, et al. "Age-dependent Alterations of Linoleic, Arachidonic and Eicosapentaenoic Acids in Renal Cortex and Medulla of Spontaneously Hypertensive Rats." Prostaglandins, vol. 27, no. 3, 1984, pp. 375-90.
Singer P, Wirth M, Gerike U, et al. Age-dependent alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of spontaneously hypertensive rats. Prostaglandins. 1984;27(3):375-90.
Singer, P., Wirth, M., Gerike, U., Gödicke, W., & Moritz, V. (1984). Age-dependent alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of spontaneously hypertensive rats. Prostaglandins, 27(3), 375-90.
Singer P, et al. Age-dependent Alterations of Linoleic, Arachidonic and Eicosapentaenoic Acids in Renal Cortex and Medulla of Spontaneously Hypertensive Rats. Prostaglandins. 1984;27(3):375-90. PubMed PMID: 6328578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-dependent alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of spontaneously hypertensive rats. AU - Singer,P, AU - Wirth,M, AU - Gerike,U, AU - Gödicke,W, AU - Moritz,V, PY - 1984/3/1/pubmed PY - 1984/3/1/medline PY - 1984/3/1/entrez SP - 375 EP - 90 JF - Prostaglandins JO - Prostaglandins VL - 27 IS - 3 N2 - The lipid content as well as the fatty acid pattern of triglycerides, free fatty acids (FFA), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were estimated in renal cortex and medulla of spontaneously hypertensive rats (SHR) and normotensive Wistar rats (WR) at 4, 8, 26 and 52 weeks of age. In general, the level of triglycerides in renal medulla appeared higher when compared with the cortex. On the other hand, PC and PE, increasing with age, were usually higher in the cortex. A decreased percentage of linoleic acid (LA) in triglycerides, of arachidonic acid (AA) in PC and of eicosapentaenoic acid (EPA) in triglycerides, FFA, PC and PE could be found in the kidneys of SHR at 8 weeks of age, i.e. during the development of hypertension. This was accompanied with a rise of AA in FFA of SHR at 8 weeks of age, which occurred with delay in WR (at 26 weeks of age). From the data presented it can be concluded that systematic alterations in the availability of individual polyunsaturated fatty acids (PUFA) in various renal lipids might be related to the onset of hypertension in SHR which should be elucidated in more detail. SN - 0090-6980 UR - https://www.unboundmedicine.com/medline/citation/6328578/Age_dependent_alterations_of_linoleic_arachidonic_and_eicosapentaenoic_acids_in_renal_cortex_and_medulla_of_spontaneously_hypertensive_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0090-6980(84)90197-7 DB - PRIME DP - Unbound Medicine ER -