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Clinical, haematological and parasitological response to treatment of visceral leishmaniasis in Kenya. A study of 64 patients.
Trop Geogr Med. 1984 Mar; 36(1):21-35.TG

Abstract

Sixty four Kenyan patients with visceral leishmaniasis were treated with sodium stibogluconate (Pentostam) (40 patients) or various combinations of Pentostam and allopurinol (24 patients). Three patients, initially considered cured after Pentostam, relapsed but responded to further treatment. Sixty two were cured and two patients died. The treatment and the clinical, haematological and parasitological response to treatment are described in detail. If follow up is impossible or unlikely it is advised to continue treatment until parasitological cure is obtained. Prolonged courses of Pentostam, which were required in some patients, resulted in cures and apparently were non toxic. Consideration is to be given to extended treatment with Pentostam before more toxic drugs such as pentamidine and amphotericin B are given.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6328709

Citation

Kager, P A., et al. "Clinical, Haematological and Parasitological Response to Treatment of Visceral Leishmaniasis in Kenya. a Study of 64 Patients." Tropical and Geographical Medicine, vol. 36, no. 1, 1984, pp. 21-35.
Kager PA, Rees PH, Manguyu FM, et al. Clinical, haematological and parasitological response to treatment of visceral leishmaniasis in Kenya. A study of 64 patients. Trop Geogr Med. 1984;36(1):21-35.
Kager, P. A., Rees, P. H., Manguyu, F. M., Bhatt, K. M., Wellde, B. T., Hockmeyer, W. T., & Lyerly, W. H. (1984). Clinical, haematological and parasitological response to treatment of visceral leishmaniasis in Kenya. A study of 64 patients. Tropical and Geographical Medicine, 36(1), 21-35.
Kager PA, et al. Clinical, Haematological and Parasitological Response to Treatment of Visceral Leishmaniasis in Kenya. a Study of 64 Patients. Trop Geogr Med. 1984;36(1):21-35. PubMed PMID: 6328709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical, haematological and parasitological response to treatment of visceral leishmaniasis in Kenya. A study of 64 patients. AU - Kager,P A, AU - Rees,P H, AU - Manguyu,F M, AU - Bhatt,K M, AU - Wellde,B T, AU - Hockmeyer,W T, AU - Lyerly,W H,Jr PY - 1984/3/1/pubmed PY - 2001/3/28/medline PY - 1984/3/1/entrez SP - 21 EP - 35 JF - Tropical and geographical medicine JO - Trop Geogr Med VL - 36 IS - 1 N2 - Sixty four Kenyan patients with visceral leishmaniasis were treated with sodium stibogluconate (Pentostam) (40 patients) or various combinations of Pentostam and allopurinol (24 patients). Three patients, initially considered cured after Pentostam, relapsed but responded to further treatment. Sixty two were cured and two patients died. The treatment and the clinical, haematological and parasitological response to treatment are described in detail. If follow up is impossible or unlikely it is advised to continue treatment until parasitological cure is obtained. Prolonged courses of Pentostam, which were required in some patients, resulted in cures and apparently were non toxic. Consideration is to be given to extended treatment with Pentostam before more toxic drugs such as pentamidine and amphotericin B are given. SN - 0041-3232 UR - https://www.unboundmedicine.com/medline/citation/6328709/Clinical_haematological_and_parasitological_response_to_treatment_of_visceral_leishmaniasis_in_Kenya__A_study_of_64_patients_ L2 - http://www.diseaseinfosearch.org/result/4166 DB - PRIME DP - Unbound Medicine ER -