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Colonic water and electrolyte transport in young and adult rats.
J Pediatr Gastroenterol Nutr. 1984 Jun; 3(3):471-4.JP

Abstract

The development of colonic water and electrolyte transport was studied in rats. The colon of 20-day-old (young) and 40-day-old (adult) rats was perfused with either a hypotonic (200 mosmol/L) or a hypertonic (450 mosmol/L) solution. The solutions had identical electrolyte contents. Polyethylene glycol was used as a marker of water absorption. Na,K-Adenosine triphosphatase (Na,K-ATPase) activity was determined in nonperfused colonic segments in 10- to 40-day-old rats. Water absorption was always higher in young rats than in adult rats. In the young rats but not in the adult rats increased osmotic pressure of the luminal fluid resulted in a significant decrease in water absorption. The secretion of K was observed only in adult rats. Na,K-ATPase activity increased significantly from 10 to 20 and from 20 to 40 days of age. The results imply that the immature colon has higher water conductivity and low active electrolyte transport.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6330339

Citation

Marin, L, and A Aperia. "Colonic Water and Electrolyte Transport in Young and Adult Rats." Journal of Pediatric Gastroenterology and Nutrition, vol. 3, no. 3, 1984, pp. 471-4.
Marin L, Aperia A. Colonic water and electrolyte transport in young and adult rats. J Pediatr Gastroenterol Nutr. 1984;3(3):471-4.
Marin, L., & Aperia, A. (1984). Colonic water and electrolyte transport in young and adult rats. Journal of Pediatric Gastroenterology and Nutrition, 3(3), 471-4.
Marin L, Aperia A. Colonic Water and Electrolyte Transport in Young and Adult Rats. J Pediatr Gastroenterol Nutr. 1984;3(3):471-4. PubMed PMID: 6330339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Colonic water and electrolyte transport in young and adult rats. AU - Marin,L, AU - Aperia,A, PY - 1984/6/1/pubmed PY - 1984/6/1/medline PY - 1984/6/1/entrez SP - 471 EP - 4 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 3 IS - 3 N2 - The development of colonic water and electrolyte transport was studied in rats. The colon of 20-day-old (young) and 40-day-old (adult) rats was perfused with either a hypotonic (200 mosmol/L) or a hypertonic (450 mosmol/L) solution. The solutions had identical electrolyte contents. Polyethylene glycol was used as a marker of water absorption. Na,K-Adenosine triphosphatase (Na,K-ATPase) activity was determined in nonperfused colonic segments in 10- to 40-day-old rats. Water absorption was always higher in young rats than in adult rats. In the young rats but not in the adult rats increased osmotic pressure of the luminal fluid resulted in a significant decrease in water absorption. The secretion of K was observed only in adult rats. Na,K-ATPase activity increased significantly from 10 to 20 and from 20 to 40 days of age. The results imply that the immature colon has higher water conductivity and low active electrolyte transport. SN - 0277-2116 UR - https://www.unboundmedicine.com/medline/citation/6330339/Colonic_water_and_electrolyte_transport_in_young_and_adult_rats_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=6330339.ui DB - PRIME DP - Unbound Medicine ER -