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Ly-2+ T cell enlargement and null cell proliferation occur at the onset of splenomegaly and autoantibody production in New Zealand Black mice.
J Immunol. 1984 Dec; 133(6):3020-5.JI

Abstract

Splenic T and B lymphocyte and null cell populations were analyzed in NZB mice as autoimmune disease developed during the first year of life. In the B lymphocytes, a progressive shift occurred from the surface IgD bright subset to the surface IgM bright subset. There was a slight increase in the ratio of Ly-2- to Ly-2+ T cells. Splenomegaly was not detected until after 40 wk of age and was primarily due to an increase in the number of null cells. This change was accompanied by an increase in the size, as determined by narrow-angle forward light scatter, of the Ly-2+ but not the Ly-2- T cells, an elevation of IgG-containing plasma cells, and the appearance of anti-erythrocyte autoantibody. The splenic B cell subset distribution and the enlargement of the Ly-2+ T cells were reflected in the peripheral blood, whereas the T cell subset ratio was not. The B cell subset alteration did not correlate with any of the other changes observed. Statistical associations were found between the ratios of T cell subsets, the enlargement of the Ly-2+ T cells, and the increased number of null cells, suggesting a linkage among those late changes that immediately precede the development of overt autoimmune disease.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6333451

Citation

Manohar, V, et al. "Ly-2+ T Cell Enlargement and Null Cell Proliferation Occur at the Onset of Splenomegaly and Autoantibody Production in New Zealand Black Mice." Journal of Immunology (Baltimore, Md. : 1950), vol. 133, no. 6, 1984, pp. 3020-5.
Manohar V, Brown EM, Leiserson WM, et al. Ly-2+ T cell enlargement and null cell proliferation occur at the onset of splenomegaly and autoantibody production in New Zealand Black mice. J Immunol. 1984;133(6):3020-5.
Manohar, V., Brown, E. M., Leiserson, W. M., Edison, L. J., & Chused, T. M. (1984). Ly-2+ T cell enlargement and null cell proliferation occur at the onset of splenomegaly and autoantibody production in New Zealand Black mice. Journal of Immunology (Baltimore, Md. : 1950), 133(6), 3020-5.
Manohar V, et al. Ly-2+ T Cell Enlargement and Null Cell Proliferation Occur at the Onset of Splenomegaly and Autoantibody Production in New Zealand Black Mice. J Immunol. 1984;133(6):3020-5. PubMed PMID: 6333451.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ly-2+ T cell enlargement and null cell proliferation occur at the onset of splenomegaly and autoantibody production in New Zealand Black mice. AU - Manohar,V, AU - Brown,E M, AU - Leiserson,W M, AU - Edison,L J, AU - Chused,T M, PY - 1984/12/1/pubmed PY - 1984/12/1/medline PY - 1984/12/1/entrez SP - 3020 EP - 5 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J Immunol VL - 133 IS - 6 N2 - Splenic T and B lymphocyte and null cell populations were analyzed in NZB mice as autoimmune disease developed during the first year of life. In the B lymphocytes, a progressive shift occurred from the surface IgD bright subset to the surface IgM bright subset. There was a slight increase in the ratio of Ly-2- to Ly-2+ T cells. Splenomegaly was not detected until after 40 wk of age and was primarily due to an increase in the number of null cells. This change was accompanied by an increase in the size, as determined by narrow-angle forward light scatter, of the Ly-2+ but not the Ly-2- T cells, an elevation of IgG-containing plasma cells, and the appearance of anti-erythrocyte autoantibody. The splenic B cell subset distribution and the enlargement of the Ly-2+ T cells were reflected in the peripheral blood, whereas the T cell subset ratio was not. The B cell subset alteration did not correlate with any of the other changes observed. Statistical associations were found between the ratios of T cell subsets, the enlargement of the Ly-2+ T cells, and the increased number of null cells, suggesting a linkage among those late changes that immediately precede the development of overt autoimmune disease. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/6333451/Ly_2+_T_cell_enlargement_and_null_cell_proliferation_occur_at_the_onset_of_splenomegaly_and_autoantibody_production_in_New_Zealand_Black_mice_ L2 - https://www.jimmunol.org/lookup/pmidlookup?view=long&pmid=6333451 DB - PRIME DP - Unbound Medicine ER -