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Changes in T and B lymphocyte subpopulations before, during and after chemotherapy for malignant melanoma.

Abstract

The behaviour of T and B lymphocyte subpopulations before, during and after chemotherapy with DTIC or CCNU was studied in 87 melanoma patients. The effect on immune status of DTIC administered as adjuvant therapy was also reported. The immunosuppressive effect was found to be higher in patients with normal pretreatment T-cell values than in patients with low pretreatment values, and it was higher in metastatic than in nonmetastatic patients. Where T and B lymphocyte subpopulations were assessed in 10 metastatic patients after each course of chemotherapy, a progressive reduction of T-lymphocytes was observed, indicating a cumulative effect of the drugs with advancing course. The reduction of T lymphocytes was mainly due to the decrease of OKT4+ cells. A normalization of T lymphocyte subpopulations was observed after the suspension of therapy. No significant decrease in the number of B cells was observed in the DTIC treated metastatic patients, whereas a significative reduction in the absolute number was found in those treated with CCNU.

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Source

MeSH

Aged
B-Lymphocytes
Dacarbazine
Female
Humans
Leukocyte Count
Lomustine
Lymphocytes
Male
Melanoma
Middle Aged
Neoplasm Metastasis
T-Lymphocytes

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6335712

Citation

TY - JOUR T1 - Changes in T and B lymphocyte subpopulations before, during and after chemotherapy for malignant melanoma. AU - Bernengo,M G, AU - Lisa,F, AU - Meregalli,M, AU - Doveil,G C, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 505 EP - 11 JF - International journal of tissue reactions JO - Int J Tissue React VL - 6 IS - 6 N2 - The behaviour of T and B lymphocyte subpopulations before, during and after chemotherapy with DTIC or CCNU was studied in 87 melanoma patients. The effect on immune status of DTIC administered as adjuvant therapy was also reported. The immunosuppressive effect was found to be higher in patients with normal pretreatment T-cell values than in patients with low pretreatment values, and it was higher in metastatic than in nonmetastatic patients. Where T and B lymphocyte subpopulations were assessed in 10 metastatic patients after each course of chemotherapy, a progressive reduction of T-lymphocytes was observed, indicating a cumulative effect of the drugs with advancing course. The reduction of T lymphocytes was mainly due to the decrease of OKT4+ cells. A normalization of T lymphocyte subpopulations was observed after the suspension of therapy. No significant decrease in the number of B cells was observed in the DTIC treated metastatic patients, whereas a significative reduction in the absolute number was found in those treated with CCNU. SN - 0250-0868 UR - https://www.unboundmedicine.com/medline/citation/6335712/Changes_in_T_and_B_lymphocyte_subpopulations_before_during_and_after_chemotherapy_for_malignant_melanoma_ L2 - https://medlineplus.gov/melanoma.html ER -