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Plasma glucose, insulin and lipid responses to high-carbohydrate low-fat diets in normal humans.
Metabolism 1983; 32(1):52-6M

Abstract

Two levels of dietary carbohydrate (40% and 60% of calories) were incorporated into typical U.S. diets and fed for 10 days each to 11 healthy volunteers. Fasting blood samples were drawn on days 8, 9, and 10 of each dietary period and analyzed for glucose, insulin, cholesterol, triglyceride (TG) and high density lipoprotein (HDL)-cholesterol concentrations. In addition, plasma glucose, insulin and TG concentrations were determined before, and for 3 hr after the noon meal on days 8 and 10. No differences were observed in fasting plasma glucose, insulin or cholesterol concentrations. However, fasting plasma TG levels were significantly elevated on the 60% carbohydrate diet, and HDL-cholesterol concentrations were significantly decreased. Furthermore, the plasma insulin and triglyceride responses to the meal tolerance test during the 60% carbohydrate dietary period were significantly elevated. These results indicate that high-carbohydrate diets lead to changes in insulin, TG, and HDL-cholesterol concentrations which have been associated with an increase in incidence of coronary artery disease.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6336816

Citation

Coulston, A M., et al. "Plasma Glucose, Insulin and Lipid Responses to High-carbohydrate Low-fat Diets in Normal Humans." Metabolism: Clinical and Experimental, vol. 32, no. 1, 1983, pp. 52-6.
Coulston AM, Liu GC, Reaven GM. Plasma glucose, insulin and lipid responses to high-carbohydrate low-fat diets in normal humans. Metab Clin Exp. 1983;32(1):52-6.
Coulston, A. M., Liu, G. C., & Reaven, G. M. (1983). Plasma glucose, insulin and lipid responses to high-carbohydrate low-fat diets in normal humans. Metabolism: Clinical and Experimental, 32(1), pp. 52-6.
Coulston AM, Liu GC, Reaven GM. Plasma Glucose, Insulin and Lipid Responses to High-carbohydrate Low-fat Diets in Normal Humans. Metab Clin Exp. 1983;32(1):52-6. PubMed PMID: 6336816.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma glucose, insulin and lipid responses to high-carbohydrate low-fat diets in normal humans. AU - Coulston,A M, AU - Liu,G C, AU - Reaven,G M, PY - 1983/1/1/pubmed PY - 1983/1/1/medline PY - 1983/1/1/entrez SP - 52 EP - 6 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 32 IS - 1 N2 - Two levels of dietary carbohydrate (40% and 60% of calories) were incorporated into typical U.S. diets and fed for 10 days each to 11 healthy volunteers. Fasting blood samples were drawn on days 8, 9, and 10 of each dietary period and analyzed for glucose, insulin, cholesterol, triglyceride (TG) and high density lipoprotein (HDL)-cholesterol concentrations. In addition, plasma glucose, insulin and TG concentrations were determined before, and for 3 hr after the noon meal on days 8 and 10. No differences were observed in fasting plasma glucose, insulin or cholesterol concentrations. However, fasting plasma TG levels were significantly elevated on the 60% carbohydrate diet, and HDL-cholesterol concentrations were significantly decreased. Furthermore, the plasma insulin and triglyceride responses to the meal tolerance test during the 60% carbohydrate dietary period were significantly elevated. These results indicate that high-carbohydrate diets lead to changes in insulin, TG, and HDL-cholesterol concentrations which have been associated with an increase in incidence of coronary artery disease. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/6336816/Plasma_glucose_insulin_and_lipid_responses_to_high_carbohydrate_low_fat_diets_in_normal_humans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0026-0495(83)90155-5 DB - PRIME DP - Unbound Medicine ER -