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[Falciparum malaria in East African tourists in spite of fansidar prevention. A contribution on increased chloroquine and pyrimethamine-sulfadoxine resistance in areas of East Africa].
Dtsch Med Wochenschr. 1983 Mar 04; 108(9):338-43.DM

Abstract

A decreased chloroquine (Resochin) sensitivity of strains of Plasmodium falciparum in certain areas of East Africa has given rise to an inappropriate change of chemoprophylaxis to pyrimethamine-sulfadoxine (Fansidar). Falciparum malaria occurred in five tourists during or after Fansidar prophylaxis. A therapeutic chloroquine-R2-resistance was observed in one seriously ill patient. In some patients the course of disease was prolonged to such an extent that the diagnosis could be established only after as much as 4 months after the end of the journey. This was in part surely caused by intake of anti-plasmodial drugs such as sulfonamides, tetracyclines and co-trimoxazol. The high mortality of falciparum malaria of nearly 10% in this country does not depend on the choice of drug prophylaxis or on problems of resistance, but still on a missed or delayed diagnosis.

Authors

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Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

ger

PubMed ID

6337809

Citation

Eichenlaub, D, et al. "[Falciparum Malaria in East African Tourists in Spite of Fansidar Prevention. a Contribution On Increased Chloroquine and Pyrimethamine-sulfadoxine Resistance in Areas of East Africa]." Deutsche Medizinische Wochenschrift (1946), vol. 108, no. 9, 1983, pp. 338-43.
Eichenlaub D, Hoffmann HG, Rögler G, et al. [Falciparum malaria in East African tourists in spite of fansidar prevention. A contribution on increased chloroquine and pyrimethamine-sulfadoxine resistance in areas of East Africa]. Dtsch Med Wochenschr. 1983;108(9):338-43.
Eichenlaub, D., Hoffmann, H. G., Rögler, G., & Weise, H. J. (1983). [Falciparum malaria in East African tourists in spite of fansidar prevention. A contribution on increased chloroquine and pyrimethamine-sulfadoxine resistance in areas of East Africa]. Deutsche Medizinische Wochenschrift (1946), 108(9), 338-43.
Eichenlaub D, et al. [Falciparum Malaria in East African Tourists in Spite of Fansidar Prevention. a Contribution On Increased Chloroquine and Pyrimethamine-sulfadoxine Resistance in Areas of East Africa]. Dtsch Med Wochenschr. 1983 Mar 4;108(9):338-43. PubMed PMID: 6337809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Falciparum malaria in East African tourists in spite of fansidar prevention. A contribution on increased chloroquine and pyrimethamine-sulfadoxine resistance in areas of East Africa]. AU - Eichenlaub,D, AU - Hoffmann,H G, AU - Rögler,G, AU - Weise,H J, PY - 1983/3/4/pubmed PY - 1983/3/4/medline PY - 1983/3/4/entrez SP - 338 EP - 43 JF - Deutsche medizinische Wochenschrift (1946) JO - Dtsch Med Wochenschr VL - 108 IS - 9 N2 - A decreased chloroquine (Resochin) sensitivity of strains of Plasmodium falciparum in certain areas of East Africa has given rise to an inappropriate change of chemoprophylaxis to pyrimethamine-sulfadoxine (Fansidar). Falciparum malaria occurred in five tourists during or after Fansidar prophylaxis. A therapeutic chloroquine-R2-resistance was observed in one seriously ill patient. In some patients the course of disease was prolonged to such an extent that the diagnosis could be established only after as much as 4 months after the end of the journey. This was in part surely caused by intake of anti-plasmodial drugs such as sulfonamides, tetracyclines and co-trimoxazol. The high mortality of falciparum malaria of nearly 10% in this country does not depend on the choice of drug prophylaxis or on problems of resistance, but still on a missed or delayed diagnosis. SN - 0012-0472 UR - https://www.unboundmedicine.com/medline/citation/6337809/[Falciparum_malaria_in_East_African_tourists_in_spite_of_fansidar_prevention__A_contribution_on_increased_chloroquine_and_pyrimethamine_sulfadoxine_resistance_in_areas_of_East_Africa]_ DB - PRIME DP - Unbound Medicine ER -