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Transferase-deficiency galactosemia: evidence for the lack of a transferase protein in galactosemic red cells.
Arch Biochem Biophys. 1983 Apr 01; 222(1):326-31.AB

Abstract

Red blood cell lysates from normal individuals, a homozygous Duarte variant, and a patient with transferase-deficiency galactosemia were challenged with rabbit antibody to pure human placental galactose-1-phosphate uridylyltransferase. Although the antibody quantitatively precipitated the enzymatically active proteins in the normal and Duarte hemolysates, the Duarte sample absorbed only about one-half as much antibody as did the normal. In contrast, the antibody did not react with the galactosemic hemolysate.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6340612

Citation

Andersen, M W., et al. "Transferase-deficiency Galactosemia: Evidence for the Lack of a Transferase Protein in Galactosemic Red Cells." Archives of Biochemistry and Biophysics, vol. 222, no. 1, 1983, pp. 326-31.
Andersen MW, Williams VP, Helmer GR, et al. Transferase-deficiency galactosemia: evidence for the lack of a transferase protein in galactosemic red cells. Arch Biochem Biophys. 1983;222(1):326-31.
Andersen, M. W., Williams, V. P., Helmer, G. R., Fried, C., & Popják, G. (1983). Transferase-deficiency galactosemia: evidence for the lack of a transferase protein in galactosemic red cells. Archives of Biochemistry and Biophysics, 222(1), 326-31.
Andersen MW, et al. Transferase-deficiency Galactosemia: Evidence for the Lack of a Transferase Protein in Galactosemic Red Cells. Arch Biochem Biophys. 1983 Apr 1;222(1):326-31. PubMed PMID: 6340612.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transferase-deficiency galactosemia: evidence for the lack of a transferase protein in galactosemic red cells. AU - Andersen,M W, AU - Williams,V P, AU - Helmer,G R,Jr AU - Fried,C, AU - Popják,G, PY - 1983/4/1/pubmed PY - 2001/3/28/medline PY - 1983/4/1/entrez SP - 326 EP - 31 JF - Archives of biochemistry and biophysics JO - Arch Biochem Biophys VL - 222 IS - 1 N2 - Red blood cell lysates from normal individuals, a homozygous Duarte variant, and a patient with transferase-deficiency galactosemia were challenged with rabbit antibody to pure human placental galactose-1-phosphate uridylyltransferase. Although the antibody quantitatively precipitated the enzymatically active proteins in the normal and Duarte hemolysates, the Duarte sample absorbed only about one-half as much antibody as did the normal. In contrast, the antibody did not react with the galactosemic hemolysate. SN - 0003-9861 UR - https://www.unboundmedicine.com/medline/citation/6340612/Transferase_deficiency_galactosemia:_evidence_for_the_lack_of_a_transferase_protein_in_galactosemic_red_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0003-9861(83)90530-1 DB - PRIME DP - Unbound Medicine ER -