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Carboxyhaemoglobin and pulmonary epithelial permeability in man.
Thorax. 1983 Feb; 38(2):129-33.T

Abstract

The effect of cigarette smoke exposure on pulmonary epithelial permeability was studied in 45 smokers and 22 non-smokers. An index of cigarette smoke exposure was obtained from the carboxyhaemoglobin concentration (HbCO%). Pulmonary epithelial permeability was proportional to the half-time clearance rate of technetium-99m-labelled diethylene triamine pentacetate (99mTc DTPA) from lung to blood (T1/2LB). The relationship between T1/2LB and HbCO% was hyperbolic in form and the data could be fitted to the quadratic formula (formula; see text) where the parameters a0, a1, and a2 represent respectively the asymptotic T1/2LB value at large carboxyhaemoglobin values and the slope and shape of the curve. The values of these parameters were a0 4.4 (2.6), a1 = 77.8 (15.5), and a2 -25.5 (9.7) (SE). This is the first demonstration of a dose-response relationship between carboxyhaemoglobin and an increased permeability of the lungs in man and provides a technique for identifying the roles of carbon monoxide and other cigarette smoke constituents in causing increased pulmonary epithelial permeability.

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Authors

Jones JG
No affiliation info available
Minty BD
No affiliation info available
Royston D
No affiliation info available
Royston JP
No affiliation info available

MeSH

AdultAgedCarboxyhemoglobinCell Membrane PermeabilityHemoglobinsHumansMiddle AgedPentetic AcidPulmonary AlveoliSmokingTechnetiumTechnetium Tc 99m PentetateTime Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6344310

Citation

Jones, J G., et al. "Carboxyhaemoglobin and Pulmonary Epithelial Permeability in Man." Thorax, vol. 38, no. 2, 1983, pp. 129-33.
Jones JG, Minty BD, Royston D, et al. Carboxyhaemoglobin and pulmonary epithelial permeability in man. Thorax. 1983;38(2):129-33.
Jones, J. G., Minty, B. D., Royston, D., & Royston, J. P. (1983). Carboxyhaemoglobin and pulmonary epithelial permeability in man. Thorax, 38(2), 129-33.
Jones JG, et al. Carboxyhaemoglobin and Pulmonary Epithelial Permeability in Man. Thorax. 1983;38(2):129-33. PubMed PMID: 6344310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carboxyhaemoglobin and pulmonary epithelial permeability in man. AU - Jones,J G, AU - Minty,B D, AU - Royston,D, AU - Royston,J P, PY - 1983/2/1/pubmed PY - 1983/2/1/medline PY - 1983/2/1/entrez SP - 129 EP - 33 JF - Thorax JO - Thorax VL - 38 IS - 2 N2 - The effect of cigarette smoke exposure on pulmonary epithelial permeability was studied in 45 smokers and 22 non-smokers. An index of cigarette smoke exposure was obtained from the carboxyhaemoglobin concentration (HbCO%). Pulmonary epithelial permeability was proportional to the half-time clearance rate of technetium-99m-labelled diethylene triamine pentacetate (99mTc DTPA) from lung to blood (T1/2LB). The relationship between T1/2LB and HbCO% was hyperbolic in form and the data could be fitted to the quadratic formula (formula; see text) where the parameters a0, a1, and a2 represent respectively the asymptotic T1/2LB value at large carboxyhaemoglobin values and the slope and shape of the curve. The values of these parameters were a0 4.4 (2.6), a1 = 77.8 (15.5), and a2 -25.5 (9.7) (SE). This is the first demonstration of a dose-response relationship between carboxyhaemoglobin and an increased permeability of the lungs in man and provides a technique for identifying the roles of carbon monoxide and other cigarette smoke constituents in causing increased pulmonary epithelial permeability. SN - 0040-6376 UR - https://www.unboundmedicine.com/medline/citation/6344310/Carboxyhaemoglobin_and_pulmonary_epithelial_permeability_in_man_ L2 - https://thorax.bmj.com/lookup/pmidlookup?view=long&pmid=6344310 DB - PRIME DP - Unbound Medicine ER -