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An in vitro model of canine immediate-type hypersensitivity reactions.
Int Arch Allergy Appl Immunol. 1976; 51(6):641-55.IA

Abstract

Fragmented lung prepared from dogs cutaneously sensitive to ascaris antigen released histamine and a slow-reacting substance of anaphylaxis-like (SRS-A) material upon antigen challenge. Passive sensitization of fragments with serum obtained from ascaris-sensitive donor dogs enhanced the release of both substances; heating (56 degrees C for 4 h) destroyed the ability of the serum to enhance release. In passively sensitized tissues isoproterenol and papaverine inhibited the release of histamine and SRS-A; propranolol antagonized the effect of isoproterenol. Carbachol enhanced the release of both substances from passively sensitized lung wheras disodium cromoglycate and aminoguanidine were without effect. It is concluded that fragmented canine lung is a useful model for study of immediate-type hypersensitivity reactions.

Authors

Krell RD
No affiliation info available
Chakrin LW
No affiliation info available

MeSH

AnimalsAntigensAscarisCarbacholCromolyn SodiumDisease Models, AnimalDogsGuanidinesHistamine ReleaseHot TemperatureHypersensitivity, ImmediateIsoproterenolLungMalePapaverinePropranololSRS-A

Pub Type(s)

Journal Article

Language

eng

PubMed ID

63451

Citation

Krell, R D., and L W. Chakrin. "An in Vitro Model of Canine Immediate-type Hypersensitivity Reactions." International Archives of Allergy and Applied Immunology, vol. 51, no. 6, 1976, pp. 641-55.
Krell RD, Chakrin LW. An in vitro model of canine immediate-type hypersensitivity reactions. Int Arch Allergy Appl Immunol. 1976;51(6):641-55.
Krell, R. D., & Chakrin, L. W. (1976). An in vitro model of canine immediate-type hypersensitivity reactions. International Archives of Allergy and Applied Immunology, 51(6), 641-55.
Krell RD, Chakrin LW. An in Vitro Model of Canine Immediate-type Hypersensitivity Reactions. Int Arch Allergy Appl Immunol. 1976;51(6):641-55. PubMed PMID: 63451.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An in vitro model of canine immediate-type hypersensitivity reactions. AU - Krell,R D, AU - Chakrin,L W, PY - 1976/1/1/pubmed PY - 1976/1/1/medline PY - 1976/1/1/entrez SP - 641 EP - 55 JF - International archives of allergy and applied immunology JO - Int Arch Allergy Appl Immunol VL - 51 IS - 6 N2 - Fragmented lung prepared from dogs cutaneously sensitive to ascaris antigen released histamine and a slow-reacting substance of anaphylaxis-like (SRS-A) material upon antigen challenge. Passive sensitization of fragments with serum obtained from ascaris-sensitive donor dogs enhanced the release of both substances; heating (56 degrees C for 4 h) destroyed the ability of the serum to enhance release. In passively sensitized tissues isoproterenol and papaverine inhibited the release of histamine and SRS-A; propranolol antagonized the effect of isoproterenol. Carbachol enhanced the release of both substances from passively sensitized lung wheras disodium cromoglycate and aminoguanidine were without effect. It is concluded that fragmented canine lung is a useful model for study of immediate-type hypersensitivity reactions. SN - 0020-5915 UR - https://www.unboundmedicine.com/medline/citation/63451/An_in_vitro_model_of_canine_immediate_type_hypersensitivity_reactions_ DB - PRIME DP - Unbound Medicine ER -