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Effect of high-carbohydrate-low-fat diets on plasma glucose, insulin and lipid responses in hypertriglyceridemic humans.

Abstract

Two levels of dietary carbohydrate (40% and 60% of calories) were incorporated into typical US diets and fed for 15 days each to eight patients with endogenous hypertriglyceridemia. Fasting blood samples were drawn on days 13, 14, and 15 of each dietary period, and analyzed for glucose, insulin, cholesterol, and triglyceride concentrations, as well as for triglyceride and cholesterol content of the various lipoprotein classes. In addition, these same measurements were made before and for three hours after the noon meal on days 14 and 15. Fasting plasma triglyceride (TG) and very-low-density lipoprotein (VLDL)-TG concentrations were significantly increased (P less than 0.005) on the low-fat-high-carbohydrate diet. In addition, integrated postprandial insulin, TG, and VLDL-TG responses to the noon meal were significantly (P less than 0.01-0.001) elevated on the low-fat-high-carbohydrate diet. No dietary-induced changes were noted in either the fasting or postprandial values of glucose cholesterol, chylomicron-TG, low-density lipoprotein-cholesterol, high-density lipoprotein (HDL)-cholesterol, HDL2-cholesterol, or HDL3-cholesterol. These results indicate that low-fat-high-carbohydrate diets accentuate the metabolic risk factors for coronary artery disease that are already present in patients with endogenous hypertriglyceridemia.

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    MeSH

    Adult
    Aged
    Blood Glucose
    Chemical Phenomena
    Chemistry
    Cholesterol
    Dietary Carbohydrates
    Dietary Fats
    Fasting
    Female
    Humans
    Hyperlipidemias
    Insulin
    Lipids
    Lipoproteins
    Male
    Middle Aged
    Triglycerides

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, Non-P.H.S.
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    6346001

    Citation

    Liu, G C., et al. "Effect of High-carbohydrate-low-fat Diets On Plasma Glucose, Insulin and Lipid Responses in Hypertriglyceridemic Humans." Metabolism: Clinical and Experimental, vol. 32, no. 8, 1983, pp. 750-3.
    Liu GC, Coulston AM, Reaven GM. Effect of high-carbohydrate-low-fat diets on plasma glucose, insulin and lipid responses in hypertriglyceridemic humans. Metab Clin Exp. 1983;32(8):750-3.
    Liu, G. C., Coulston, A. M., & Reaven, G. M. (1983). Effect of high-carbohydrate-low-fat diets on plasma glucose, insulin and lipid responses in hypertriglyceridemic humans. Metabolism: Clinical and Experimental, 32(8), pp. 750-3.
    Liu GC, Coulston AM, Reaven GM. Effect of High-carbohydrate-low-fat Diets On Plasma Glucose, Insulin and Lipid Responses in Hypertriglyceridemic Humans. Metab Clin Exp. 1983;32(8):750-3. PubMed PMID: 6346001.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of high-carbohydrate-low-fat diets on plasma glucose, insulin and lipid responses in hypertriglyceridemic humans. AU - Liu,G C, AU - Coulston,A M, AU - Reaven,G M, PY - 1983/8/1/pubmed PY - 1983/8/1/medline PY - 1983/8/1/entrez SP - 750 EP - 3 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 32 IS - 8 N2 - Two levels of dietary carbohydrate (40% and 60% of calories) were incorporated into typical US diets and fed for 15 days each to eight patients with endogenous hypertriglyceridemia. Fasting blood samples were drawn on days 13, 14, and 15 of each dietary period, and analyzed for glucose, insulin, cholesterol, and triglyceride concentrations, as well as for triglyceride and cholesterol content of the various lipoprotein classes. In addition, these same measurements were made before and for three hours after the noon meal on days 14 and 15. Fasting plasma triglyceride (TG) and very-low-density lipoprotein (VLDL)-TG concentrations were significantly increased (P less than 0.005) on the low-fat-high-carbohydrate diet. In addition, integrated postprandial insulin, TG, and VLDL-TG responses to the noon meal were significantly (P less than 0.01-0.001) elevated on the low-fat-high-carbohydrate diet. No dietary-induced changes were noted in either the fasting or postprandial values of glucose cholesterol, chylomicron-TG, low-density lipoprotein-cholesterol, high-density lipoprotein (HDL)-cholesterol, HDL2-cholesterol, or HDL3-cholesterol. These results indicate that low-fat-high-carbohydrate diets accentuate the metabolic risk factors for coronary artery disease that are already present in patients with endogenous hypertriglyceridemia. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/6346001/Effect_of_high_carbohydrate_low_fat_diets_on_plasma_glucose_insulin_and_lipid_responses_in_hypertriglyceridemic_humans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0026-0495(83)90103-8 DB - PRIME DP - Unbound Medicine ER -