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Comparison of contraceptive acceptability of levonorgestrel and ethinyl oestradiol administered in one three-phasic (Trionetta) and one monophasic (Neovletta) version.
Contraception. 1983 May; 27(5):439-52.C

Abstract

In a Swedish multicenter study, a total number of 835 women completed a total of 6472 treatment cycles. Half of them were allotted at random to use the monophasic oral contraceptive Neovletta, also known as Microgynon 30 (30 micrograms ethinyl oestradiol + 150 micrograms levonorgestrel in each tablet). The second half was allotted to Trionetta, also known as Triquilar, Trigynon and Logynon (6 tablets with 30 micrograms ethinyl oestradiol + 50 micrograms levonorgestrel, 5 tablets with 40 micrograms ethinyl oestradiol + 75 micrograms levonorgestrel and 10 tablets with 30 micrograms ethinyl oestradiol + 125 micrograms levonorgestrel). The latter version was also present in a 28-day version containing in addition 7 "placebo" tablets to be used in the otherwise tablet-free interval. The contraceptive reliability was excellent although one pregnancy occurred in the three-phase version. It could be attributed to patient failure. In all aspects of bleeding control, the three-phasic pill proved to be superior to the reference monophasic preparation. The extreme low incidence of missed withdrawal bleeding and stability already during the first months of use are noteworthy features. For both preparations, continuation rate was at six months of use about 85% and at 12 months it was a similar figure. The most common reason for withdrawal was bleeding, about 5% each for both preparation. No serious side-effects were reported. The study clearly indicates that the three-phasic version is a major improvement in spite of a considerably decreased total dose of the gestagen.

Authors

No affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

6349925

Citation

Carlborg, L. "Comparison of Contraceptive Acceptability of Levonorgestrel and Ethinyl Oestradiol Administered in One Three-phasic (Trionetta) and One Monophasic (Neovletta) Version." Contraception, vol. 27, no. 5, 1983, pp. 439-52.
Carlborg L. Comparison of contraceptive acceptability of levonorgestrel and ethinyl oestradiol administered in one three-phasic (Trionetta) and one monophasic (Neovletta) version. Contraception. 1983;27(5):439-52.
Carlborg, L. (1983). Comparison of contraceptive acceptability of levonorgestrel and ethinyl oestradiol administered in one three-phasic (Trionetta) and one monophasic (Neovletta) version. Contraception, 27(5), 439-52.
Carlborg L. Comparison of Contraceptive Acceptability of Levonorgestrel and Ethinyl Oestradiol Administered in One Three-phasic (Trionetta) and One Monophasic (Neovletta) Version. Contraception. 1983;27(5):439-52. PubMed PMID: 6349925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of contraceptive acceptability of levonorgestrel and ethinyl oestradiol administered in one three-phasic (Trionetta) and one monophasic (Neovletta) version. A1 - Carlborg,L, PY - 1983/5/1/pubmed PY - 1983/5/1/medline PY - 1983/5/1/entrez KW - Bleeding KW - Central Nervous System Effects KW - Comparative Studies KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Estrogen KW - Contraceptive Agents, Female--side effects KW - Contraceptive Agents, Progestin KW - Contraceptive Agents--side effects KW - Contraceptive Effectiveness KW - Contraceptive Methods KW - Contraceptive Methods--side effects KW - Depression KW - Developed Countries KW - Diseases KW - Dysmenorrhea KW - Ethinyl Estradiol KW - Europe KW - Family Planning KW - Gastrointestinal Effects KW - Headache KW - Levonorgestrel KW - Menstruation Disorders KW - Metrorrhagia KW - Northern Europe KW - Oral Contraceptives, Combined KW - Oral Contraceptives--side effects KW - Reproductive Control Agents KW - Research Methodology KW - Scandinavia KW - Signs And Symptoms KW - Studies KW - Sweden KW - Use-effectiveness SP - 439 EP - 52 JF - Contraception JO - Contraception VL - 27 IS - 5 N2 - In a Swedish multicenter study, a total number of 835 women completed a total of 6472 treatment cycles. Half of them were allotted at random to use the monophasic oral contraceptive Neovletta, also known as Microgynon 30 (30 micrograms ethinyl oestradiol + 150 micrograms levonorgestrel in each tablet). The second half was allotted to Trionetta, also known as Triquilar, Trigynon and Logynon (6 tablets with 30 micrograms ethinyl oestradiol + 50 micrograms levonorgestrel, 5 tablets with 40 micrograms ethinyl oestradiol + 75 micrograms levonorgestrel and 10 tablets with 30 micrograms ethinyl oestradiol + 125 micrograms levonorgestrel). The latter version was also present in a 28-day version containing in addition 7 "placebo" tablets to be used in the otherwise tablet-free interval. The contraceptive reliability was excellent although one pregnancy occurred in the three-phase version. It could be attributed to patient failure. In all aspects of bleeding control, the three-phasic pill proved to be superior to the reference monophasic preparation. The extreme low incidence of missed withdrawal bleeding and stability already during the first months of use are noteworthy features. For both preparations, continuation rate was at six months of use about 85% and at 12 months it was a similar figure. The most common reason for withdrawal was bleeding, about 5% each for both preparation. No serious side-effects were reported. The study clearly indicates that the three-phasic version is a major improvement in spite of a considerably decreased total dose of the gestagen. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/6349925/Comparison_of_contraceptive_acceptability_of_levonorgestrel_and_ethinyl_oestradiol_administered_in_one_three_phasic__Trionetta__and_one_monophasic__Neovletta__version_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0010-7824(83)90041-0 DB - PRIME DP - Unbound Medicine ER -