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Divalent cations in essential hypertension. Relations between serum ionized calcium, magnesium, and plasma renin activity.
N Engl J Med 1983; 309(15):888-91NEJM

Abstract

We studied the relation of plasma renin activity to serum levels of ionized calcium and magnesium in 102 normotensive patients and in 98 patients with essential hypertension who were divided into low-renin, normal-renin, and high-renin groups. Serum magnesium levels were higher in patients with low-renin hypertension and lower in patients with high-renin hypertension than in those with normal-renin hypertension (P less than 0.025 for both comparisons) or in normotensive controls (P less than 0.005, P less than 0.05, respectively). In contrast, serum levels of ionized calcium were lower in patients with low-renin hypertension and higher in patients with high-renin hypertension than in those with normal-renin hypertension (P less than 0.001, P less than 0.05, respectively) or in normotensive controls (P less than 0.001, P less than 0.05, respectively). Altogether, the range of plasma renin activity in essential hypertension shows a continuous negative correlation with the serum magnesium level (r = -0.60, P less than 0.001) and a positive correlation with the serum ionized calcium level (r = 0.44, P less than 0.001). Accordingly, plasma renin activity in hypertension may reflect or contribute to changes in calcium and magnesium fluxes across cell membranes.

Authors

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Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

6350880

Citation

Resnick, L M., et al. "Divalent Cations in Essential Hypertension. Relations Between Serum Ionized Calcium, Magnesium, and Plasma Renin Activity." The New England Journal of Medicine, vol. 309, no. 15, 1983, pp. 888-91.
Resnick LM, Laragh JH, Sealey JE, et al. Divalent cations in essential hypertension. Relations between serum ionized calcium, magnesium, and plasma renin activity. N Engl J Med. 1983;309(15):888-91.
Resnick, L. M., Laragh, J. H., Sealey, J. E., & Alderman, M. H. (1983). Divalent cations in essential hypertension. Relations between serum ionized calcium, magnesium, and plasma renin activity. The New England Journal of Medicine, 309(15), pp. 888-91.
Resnick LM, et al. Divalent Cations in Essential Hypertension. Relations Between Serum Ionized Calcium, Magnesium, and Plasma Renin Activity. N Engl J Med. 1983 Oct 13;309(15):888-91. PubMed PMID: 6350880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Divalent cations in essential hypertension. Relations between serum ionized calcium, magnesium, and plasma renin activity. AU - Resnick,L M, AU - Laragh,J H, AU - Sealey,J E, AU - Alderman,M H, PY - 1983/10/13/pubmed PY - 1983/10/13/medline PY - 1983/10/13/entrez SP - 888 EP - 91 JF - The New England journal of medicine JO - N. Engl. J. Med. VL - 309 IS - 15 N2 - We studied the relation of plasma renin activity to serum levels of ionized calcium and magnesium in 102 normotensive patients and in 98 patients with essential hypertension who were divided into low-renin, normal-renin, and high-renin groups. Serum magnesium levels were higher in patients with low-renin hypertension and lower in patients with high-renin hypertension than in those with normal-renin hypertension (P less than 0.025 for both comparisons) or in normotensive controls (P less than 0.005, P less than 0.05, respectively). In contrast, serum levels of ionized calcium were lower in patients with low-renin hypertension and higher in patients with high-renin hypertension than in those with normal-renin hypertension (P less than 0.001, P less than 0.05, respectively) or in normotensive controls (P less than 0.001, P less than 0.05, respectively). Altogether, the range of plasma renin activity in essential hypertension shows a continuous negative correlation with the serum magnesium level (r = -0.60, P less than 0.001) and a positive correlation with the serum ionized calcium level (r = 0.44, P less than 0.001). Accordingly, plasma renin activity in hypertension may reflect or contribute to changes in calcium and magnesium fluxes across cell membranes. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/6350880/Divalent_cations_in_essential_hypertension__Relations_between_serum_ionized_calcium_magnesium_and_plasma_renin_activity_ L2 - http://www.nejm.org/doi/full/10.1056/NEJM198310133091504?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -