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Stimulation of vessel wall prostacyclin by selective thromboxane synthetase inhibitor OKY 1581.
Prostaglandins Leukot Med. 1983 Sep; 12(1):49-52.PL

Abstract

Human umbilical veins have been shown to produce small amounts of TXA2 in addition to PGI2. We measured relative TXA2 and PGI2 production by umbilical veins in the presence of selective TXA2 synthetase inhibitor OKY 1581. OKY 1581 treatment resulted in inhibition of TXA2 but a marked increase in PGI2 release, which may relate to diversion of cyclic endoperoxides to PGI2 pathway or to removal of a feedback control at the level of AA mobilization.

Authors

Mehta J
No affiliation info available
Mehta P
No affiliation info available
Ostrowski N
No affiliation info available

MeSH

6-Ketoprostaglandin F1 alphaAcrylatesBlood VesselsEpoprostenolHumansIndomethacinMethacrylatesOxidoreductasesThromboxane A2Thromboxane B2Thromboxane-A SynthaseThromboxanesVasoconstriction

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6356153

Citation

Mehta, J, et al. "Stimulation of Vessel Wall Prostacyclin By Selective Thromboxane Synthetase Inhibitor OKY 1581." Prostaglandins, Leukotrienes, and Medicine, vol. 12, no. 1, 1983, pp. 49-52.
Mehta J, Mehta P, Ostrowski N. Stimulation of vessel wall prostacyclin by selective thromboxane synthetase inhibitor OKY 1581. Prostaglandins Leukot Med. 1983;12(1):49-52.
Mehta, J., Mehta, P., & Ostrowski, N. (1983). Stimulation of vessel wall prostacyclin by selective thromboxane synthetase inhibitor OKY 1581. Prostaglandins, Leukotrienes, and Medicine, 12(1), 49-52.
Mehta J, Mehta P, Ostrowski N. Stimulation of Vessel Wall Prostacyclin By Selective Thromboxane Synthetase Inhibitor OKY 1581. Prostaglandins Leukot Med. 1983;12(1):49-52. PubMed PMID: 6356153.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stimulation of vessel wall prostacyclin by selective thromboxane synthetase inhibitor OKY 1581. AU - Mehta,J, AU - Mehta,P, AU - Ostrowski,N, PY - 1983/9/1/pubmed PY - 1983/9/1/medline PY - 1983/9/1/entrez SP - 49 EP - 52 JF - Prostaglandins, leukotrienes, and medicine JO - Prostaglandins Leukot Med VL - 12 IS - 1 N2 - Human umbilical veins have been shown to produce small amounts of TXA2 in addition to PGI2. We measured relative TXA2 and PGI2 production by umbilical veins in the presence of selective TXA2 synthetase inhibitor OKY 1581. OKY 1581 treatment resulted in inhibition of TXA2 but a marked increase in PGI2 release, which may relate to diversion of cyclic endoperoxides to PGI2 pathway or to removal of a feedback control at the level of AA mobilization. SN - 0262-1746 UR - https://www.unboundmedicine.com/medline/citation/6356153/Stimulation_of_vessel_wall_prostacyclin_by_selective_thromboxane_synthetase_inhibitor_OKY_1581_ DB - PRIME DP - Unbound Medicine ER -
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