TY - JOUR T1 - Prevention of acute aspirin-induced gastric mucosal injury by 15-R-15 methyl prostaglandin E2: an endoscopic study. AU - Gilbert,D A, AU - Surawicz,C M, AU - Silverstein,F E, AU - Weinberg,C R, AU - Saunders,D R, AU - Feld,A D, AU - Sanford,R L, AU - Bergman,D, AU - Washington,P, PY - 1984/2/1/pubmed PY - 1984/2/1/medline PY - 1984/2/1/entrez SP - 339 EP - 45 JF - Gastroenterology JO - Gastroenterology VL - 86 IS - 2 N2 - The deleterious effects of aspirin on gastric mucosa have been well documented in experimental and clinical studies. Prostaglandins offer a potential method by which this injury may be prevented. In these studies, we developed a single-dose endoscopic assay system of aspirin-induced gastric mucosal injury in normal volunteers. With this system, 27 of 30 volunteers (90%) demonstrated severe mucosal injury after ingestion of aspirin. Subsequently, we evaluated whether pretreatment with 15-R-15 methyl prostaglandin E2 prevented severe injury after ingestion of aspirin. Following an initial dose-response study, a double-blind crossover trial was performed using pretreatment with placebo or with 10-micrograms doses of 15-R-15 methyl prostaglandin E2 for 24 h before treatment with aspirin. The results of this trial indicate that prostaglandin pretreatment significantly prevented the occurrence of endoscopically visible severe gastric mucosal injury after single-dose aspirin administration. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/6360786/Prevention_of_acute_aspirin_induced_gastric_mucosal_injury_by_15_R_15_methyl_prostaglandin_E2:_an_endoscopic_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016508584000263 DB - PRIME DP - Unbound Medicine ER -