Tags

Type your tag names separated by a space and hit enter

Prevention of acute aspirin-induced gastric mucosal injury by 15-R-15 methyl prostaglandin E2: an endoscopic study.
Gastroenterology. 1984 Feb; 86(2):339-45.G

Abstract

The deleterious effects of aspirin on gastric mucosa have been well documented in experimental and clinical studies. Prostaglandins offer a potential method by which this injury may be prevented. In these studies, we developed a single-dose endoscopic assay system of aspirin-induced gastric mucosal injury in normal volunteers. With this system, 27 of 30 volunteers (90%) demonstrated severe mucosal injury after ingestion of aspirin. Subsequently, we evaluated whether pretreatment with 15-R-15 methyl prostaglandin E2 prevented severe injury after ingestion of aspirin. Following an initial dose-response study, a double-blind crossover trial was performed using pretreatment with placebo or with 10-micrograms doses of 15-R-15 methyl prostaglandin E2 for 24 h before treatment with aspirin. The results of this trial indicate that prostaglandin pretreatment significantly prevented the occurrence of endoscopically visible severe gastric mucosal injury after single-dose aspirin administration.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6360786

Citation

Gilbert, D A., et al. "Prevention of Acute Aspirin-induced Gastric Mucosal Injury By 15-R-15 Methyl Prostaglandin E2: an Endoscopic Study." Gastroenterology, vol. 86, no. 2, 1984, pp. 339-45.
Gilbert DA, Surawicz CM, Silverstein FE, et al. Prevention of acute aspirin-induced gastric mucosal injury by 15-R-15 methyl prostaglandin E2: an endoscopic study. Gastroenterology. 1984;86(2):339-45.
Gilbert, D. A., Surawicz, C. M., Silverstein, F. E., Weinberg, C. R., Saunders, D. R., Feld, A. D., Sanford, R. L., Bergman, D., & Washington, P. (1984). Prevention of acute aspirin-induced gastric mucosal injury by 15-R-15 methyl prostaglandin E2: an endoscopic study. Gastroenterology, 86(2), 339-45.
Gilbert DA, et al. Prevention of Acute Aspirin-induced Gastric Mucosal Injury By 15-R-15 Methyl Prostaglandin E2: an Endoscopic Study. Gastroenterology. 1984;86(2):339-45. PubMed PMID: 6360786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of acute aspirin-induced gastric mucosal injury by 15-R-15 methyl prostaglandin E2: an endoscopic study. AU - Gilbert,D A, AU - Surawicz,C M, AU - Silverstein,F E, AU - Weinberg,C R, AU - Saunders,D R, AU - Feld,A D, AU - Sanford,R L, AU - Bergman,D, AU - Washington,P, PY - 1984/2/1/pubmed PY - 1984/2/1/medline PY - 1984/2/1/entrez SP - 339 EP - 45 JF - Gastroenterology JO - Gastroenterology VL - 86 IS - 2 N2 - The deleterious effects of aspirin on gastric mucosa have been well documented in experimental and clinical studies. Prostaglandins offer a potential method by which this injury may be prevented. In these studies, we developed a single-dose endoscopic assay system of aspirin-induced gastric mucosal injury in normal volunteers. With this system, 27 of 30 volunteers (90%) demonstrated severe mucosal injury after ingestion of aspirin. Subsequently, we evaluated whether pretreatment with 15-R-15 methyl prostaglandin E2 prevented severe injury after ingestion of aspirin. Following an initial dose-response study, a double-blind crossover trial was performed using pretreatment with placebo or with 10-micrograms doses of 15-R-15 methyl prostaglandin E2 for 24 h before treatment with aspirin. The results of this trial indicate that prostaglandin pretreatment significantly prevented the occurrence of endoscopically visible severe gastric mucosal injury after single-dose aspirin administration. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/6360786/Prevention_of_acute_aspirin_induced_gastric_mucosal_injury_by_15_R_15_methyl_prostaglandin_E2:_an_endoscopic_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016508584000263 DB - PRIME DP - Unbound Medicine ER -