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Controlled trial of propranolol for the prevention of recurrent variceal hemorrhage in patients with cirrhosis.
N Engl J Med. 1983 Dec 22; 309(25):1539-42.NEJM

Abstract

We conducted a prospective randomized trial of propranolol for the prevention of recurrent variceal bleeding in 48 patients with cirrhosis of the liver. During a follow-up period of up to 21 months, 12 of 26 patients in the propranolol group and 11 of 22 in the control group had rebleeding from esophageal varices. There was no significant difference in rebleeding between the two groups. This contrasts with a previous report of the efficacy of propranolol in preventing recurrent gastrointestinal bleeding in alcoholic cirrhosis. The difference in results may be due to the inclusion in our study of patients with other causes of cirrhosis and more severe liver disease. Propranolol may not be indicated for the prophylaxis of variceal rebleeding in such patients, and we advocate that its use be limited at present to controlled clinical trials.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6361553

Citation

Burroughs, A K., et al. "Controlled Trial of Propranolol for the Prevention of Recurrent Variceal Hemorrhage in Patients With Cirrhosis." The New England Journal of Medicine, vol. 309, no. 25, 1983, pp. 1539-42.
Burroughs AK, Jenkins WJ, Sherlock S, et al. Controlled trial of propranolol for the prevention of recurrent variceal hemorrhage in patients with cirrhosis. N Engl J Med. 1983;309(25):1539-42.
Burroughs, A. K., Jenkins, W. J., Sherlock, S., Dunk, A., Walt, R. P., Osuafor, T. O., Mackie, S., & Dick, R. (1983). Controlled trial of propranolol for the prevention of recurrent variceal hemorrhage in patients with cirrhosis. The New England Journal of Medicine, 309(25), 1539-42.
Burroughs AK, et al. Controlled Trial of Propranolol for the Prevention of Recurrent Variceal Hemorrhage in Patients With Cirrhosis. N Engl J Med. 1983 Dec 22;309(25):1539-42. PubMed PMID: 6361553.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Controlled trial of propranolol for the prevention of recurrent variceal hemorrhage in patients with cirrhosis. AU - Burroughs,A K, AU - Jenkins,W J, AU - Sherlock,S, AU - Dunk,A, AU - Walt,R P, AU - Osuafor,T O, AU - Mackie,S, AU - Dick,R, PY - 1983/12/22/pubmed PY - 1983/12/22/medline PY - 1983/12/22/entrez SP - 1539 EP - 42 JF - The New England journal of medicine JO - N Engl J Med VL - 309 IS - 25 N2 - We conducted a prospective randomized trial of propranolol for the prevention of recurrent variceal bleeding in 48 patients with cirrhosis of the liver. During a follow-up period of up to 21 months, 12 of 26 patients in the propranolol group and 11 of 22 in the control group had rebleeding from esophageal varices. There was no significant difference in rebleeding between the two groups. This contrasts with a previous report of the efficacy of propranolol in preventing recurrent gastrointestinal bleeding in alcoholic cirrhosis. The difference in results may be due to the inclusion in our study of patients with other causes of cirrhosis and more severe liver disease. Propranolol may not be indicated for the prophylaxis of variceal rebleeding in such patients, and we advocate that its use be limited at present to controlled clinical trials. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/6361553/Controlled_trial_of_propranolol_for_the_prevention_of_recurrent_variceal_hemorrhage_in_patients_with_cirrhosis_ DB - PRIME DP - Unbound Medicine ER -