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Vagal control of gastrin release in the dog: pathways for stimulation and inhibition.
Surgery. 1984 Jan; 95(1):34-7.S

Abstract

The vagus has a dual effect on gastrin: it both stimulates and inhibits its release. To determine the gastric vagal pathways for these opposing effects, plasma gastrin and acid responses to meal (intragastric titration of 15% liver extract, pH 5.5) and to insulin (0.5 U regular insulin intravenously) were studied in seven dogs in three consecutive stages: a control stage, after antral vagotomy (AV), and after subsequent proximal gastric vagotomy (PGV). AV abolished the plasma gastrin response to insulin but had no effect on either basal or meal-stimulated gastrin release. Subsequent PGV caused significant elevation in basal plasma gastrin concentration, no further change in the gastrin response to insulin, but a significant increase in meal-stimulated gastrin release. AV decreased acid response to insulin nonsignificantly and had no effect on meal-stimulated acid secretion. Subsequent PGV reduced by 90% the acid response to insulin, had negligible effect on the gastric fistula acid response to meal, but increased Heidenhain pouch response sixfold. These studies show that vagal stimulation of gastrin release is mediated along direct antral vagal pathways, while vagal inhibition requires intact vagal fibers to the proximal stomach. The mechanism by which the fundic vagal pathways exert an inhibitory influence on the G cell in the antrum is yet to be elucidated.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6362046

Citation

Debas, H T., et al. "Vagal Control of Gastrin Release in the Dog: Pathways for Stimulation and Inhibition." Surgery, vol. 95, no. 1, 1984, pp. 34-7.
Debas HT, Hollinshead J, Seal A, et al. Vagal control of gastrin release in the dog: pathways for stimulation and inhibition. Surgery. 1984;95(1):34-7.
Debas, H. T., Hollinshead, J., Seal, A., Soon-Shiong, P., & Walsh, J. H. (1984). Vagal control of gastrin release in the dog: pathways for stimulation and inhibition. Surgery, 95(1), 34-7.
Debas HT, et al. Vagal Control of Gastrin Release in the Dog: Pathways for Stimulation and Inhibition. Surgery. 1984;95(1):34-7. PubMed PMID: 6362046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vagal control of gastrin release in the dog: pathways for stimulation and inhibition. AU - Debas,H T, AU - Hollinshead,J, AU - Seal,A, AU - Soon-Shiong,P, AU - Walsh,J H, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 34 EP - 7 JF - Surgery JO - Surgery VL - 95 IS - 1 N2 - The vagus has a dual effect on gastrin: it both stimulates and inhibits its release. To determine the gastric vagal pathways for these opposing effects, plasma gastrin and acid responses to meal (intragastric titration of 15% liver extract, pH 5.5) and to insulin (0.5 U regular insulin intravenously) were studied in seven dogs in three consecutive stages: a control stage, after antral vagotomy (AV), and after subsequent proximal gastric vagotomy (PGV). AV abolished the plasma gastrin response to insulin but had no effect on either basal or meal-stimulated gastrin release. Subsequent PGV caused significant elevation in basal plasma gastrin concentration, no further change in the gastrin response to insulin, but a significant increase in meal-stimulated gastrin release. AV decreased acid response to insulin nonsignificantly and had no effect on meal-stimulated acid secretion. Subsequent PGV reduced by 90% the acid response to insulin, had negligible effect on the gastric fistula acid response to meal, but increased Heidenhain pouch response sixfold. These studies show that vagal stimulation of gastrin release is mediated along direct antral vagal pathways, while vagal inhibition requires intact vagal fibers to the proximal stomach. The mechanism by which the fundic vagal pathways exert an inhibitory influence on the G cell in the antrum is yet to be elucidated. SN - 0039-6060 UR - https://www.unboundmedicine.com/medline/citation/6362046/Vagal_control_of_gastrin_release_in_the_dog:_pathways_for_stimulation_and_inhibition_ DB - PRIME DP - Unbound Medicine ER -