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Direct immunofluorescence in recurrent aphthous ulcers and Behçet's disease.
Dermatologica. 1983; 167(6):293-8.D

Abstract

Direct immunofluorescence (IF) investigations in oral aphthae were performed in 17 patients with recurrent aphthous ulcers (RAU) and in 9 patients with Behçet's disease (BD). In addition, cutaneous hyperreactivity lesions from 2 BD patients were examined. The results were compared to direct IF findings in 28 patients with nonaphthous oral diseases. There was no difference between direct IF on oral aphthae in RAU compared to BD. Deposition of C3 in vessel walls of the subepithelial connective tissue was observed in 13 of 17 patients with RAU and in all patients with BD. IgM deposits in vessel walls were found in 5 RAU and 3 BD patients. Deposition of C1q or C4 was not present. By contrast, IgG and/or IgM, C1q, C3 and C4 were detected in dermal vessel walls of skin hyperreactivity lesions from 2 BD patients. This finding is considered to be a true immune complex vasculitis. Compared to nonaphthous oral lesions, oral aphthae of BD and RAU were characterized by C3 deposition in the subepithelial vessel walls.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

6363150

Citation

Reimer, G, et al. "Direct Immunofluorescence in Recurrent Aphthous Ulcers and Behçet's Disease." Dermatologica, vol. 167, no. 6, 1983, pp. 293-8.
Reimer G, Luckner L, Hornstein OP. Direct immunofluorescence in recurrent aphthous ulcers and Behçet's disease. Dermatologica. 1983;167(6):293-8.
Reimer, G., Luckner, L., & Hornstein, O. P. (1983). Direct immunofluorescence in recurrent aphthous ulcers and Behçet's disease. Dermatologica, 167(6), 293-8.
Reimer G, Luckner L, Hornstein OP. Direct Immunofluorescence in Recurrent Aphthous Ulcers and Behçet's Disease. Dermatologica. 1983;167(6):293-8. PubMed PMID: 6363150.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Direct immunofluorescence in recurrent aphthous ulcers and Behçet's disease. AU - Reimer,G, AU - Luckner,L, AU - Hornstein,O P, PY - 1983/1/1/pubmed PY - 1983/1/1/medline PY - 1983/1/1/entrez SP - 293 EP - 8 JF - Dermatologica JO - Dermatologica VL - 167 IS - 6 N2 - Direct immunofluorescence (IF) investigations in oral aphthae were performed in 17 patients with recurrent aphthous ulcers (RAU) and in 9 patients with Behçet's disease (BD). In addition, cutaneous hyperreactivity lesions from 2 BD patients were examined. The results were compared to direct IF findings in 28 patients with nonaphthous oral diseases. There was no difference between direct IF on oral aphthae in RAU compared to BD. Deposition of C3 in vessel walls of the subepithelial connective tissue was observed in 13 of 17 patients with RAU and in all patients with BD. IgM deposits in vessel walls were found in 5 RAU and 3 BD patients. Deposition of C1q or C4 was not present. By contrast, IgG and/or IgM, C1q, C3 and C4 were detected in dermal vessel walls of skin hyperreactivity lesions from 2 BD patients. This finding is considered to be a true immune complex vasculitis. Compared to nonaphthous oral lesions, oral aphthae of BD and RAU were characterized by C3 deposition in the subepithelial vessel walls. SN - 0011-9075 UR - https://www.unboundmedicine.com/medline/citation/6363150/Direct_immunofluorescence_in_recurrent_aphthous_ulcers_and_Behçet's_disease_ L2 - http://www.diseaseinfosearch.org/result/780 DB - PRIME DP - Unbound Medicine ER -