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Altered gastric emptying and prevention of radiation-induced vomiting in dogs.
Gastroenterology. 1984 Mar; 86(3):444-8.G

Abstract

The relation between radiation-induced vomiting and gastric emptying is unclear and the treatment of this condition is not established. We explored, therefore, (a) the effect of cobalt 60 irradiation on gastric emptying of solids and liquids and (b) the possibility of preventing radiation-induced vomiting with the dopamine antagonist, domperidone. Twenty dogs were studied on two separate days, blindly and in random order, after i.v. injection of either a placebo or 0.06 mg/kg domperidone. On a third day, they received 8 Gy (800 rads) whole body irradiation with cobalt 60 gamma-rays after either placebo (n = 10) or domperidone (n = 10). Before each study, each dog was fed chicken liver tagged in vivo with 99mTc-sulfur colloid (solid marker), and water containing 111In-diethylenetriamine pentaacetic acid (liquid marker). Dogs were placed in a Pavlov stand for the subsequent 3 h and radionuclide imaging was performed at 10-min intervals. Irradiation produced vomiting in 9 of 10 dogs given placebo but only in 1 of 10 dogs pretreated with domperidone (p less than 0.01). Gastric emptying of liquids and solids was significantly suppressed by irradiation (p less than 0.01) after both placebo and domperidone. These results demonstrate that radiation-induced vomiting is accompanied by suppression of gastric emptying. Furthermore, domperidone prevents vomiting produced by ionizing radiation but does not alter the accompanying delay of gastric emptying.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6363196

Citation

Dubois, A, et al. "Altered Gastric Emptying and Prevention of Radiation-induced Vomiting in Dogs." Gastroenterology, vol. 86, no. 3, 1984, pp. 444-8.
Dubois A, Jacobus JP, Grissom MP, et al. Altered gastric emptying and prevention of radiation-induced vomiting in dogs. Gastroenterology. 1984;86(3):444-8.
Dubois, A., Jacobus, J. P., Grissom, M. P., Eng, R. R., & Conklin, J. J. (1984). Altered gastric emptying and prevention of radiation-induced vomiting in dogs. Gastroenterology, 86(3), 444-8.
Dubois A, et al. Altered Gastric Emptying and Prevention of Radiation-induced Vomiting in Dogs. Gastroenterology. 1984;86(3):444-8. PubMed PMID: 6363196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Altered gastric emptying and prevention of radiation-induced vomiting in dogs. AU - Dubois,A, AU - Jacobus,J P, AU - Grissom,M P, AU - Eng,R R, AU - Conklin,J J, PY - 1984/3/1/pubmed PY - 1984/3/1/medline PY - 1984/3/1/entrez SP - 444 EP - 8 JF - Gastroenterology JO - Gastroenterology VL - 86 IS - 3 N2 - The relation between radiation-induced vomiting and gastric emptying is unclear and the treatment of this condition is not established. We explored, therefore, (a) the effect of cobalt 60 irradiation on gastric emptying of solids and liquids and (b) the possibility of preventing radiation-induced vomiting with the dopamine antagonist, domperidone. Twenty dogs were studied on two separate days, blindly and in random order, after i.v. injection of either a placebo or 0.06 mg/kg domperidone. On a third day, they received 8 Gy (800 rads) whole body irradiation with cobalt 60 gamma-rays after either placebo (n = 10) or domperidone (n = 10). Before each study, each dog was fed chicken liver tagged in vivo with 99mTc-sulfur colloid (solid marker), and water containing 111In-diethylenetriamine pentaacetic acid (liquid marker). Dogs were placed in a Pavlov stand for the subsequent 3 h and radionuclide imaging was performed at 10-min intervals. Irradiation produced vomiting in 9 of 10 dogs given placebo but only in 1 of 10 dogs pretreated with domperidone (p less than 0.01). Gastric emptying of liquids and solids was significantly suppressed by irradiation (p less than 0.01) after both placebo and domperidone. These results demonstrate that radiation-induced vomiting is accompanied by suppression of gastric emptying. Furthermore, domperidone prevents vomiting produced by ionizing radiation but does not alter the accompanying delay of gastric emptying. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/6363196/Altered_gastric_emptying_and_prevention_of_radiation_induced_vomiting_in_dogs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016508584000536 DB - PRIME DP - Unbound Medicine ER -